Prss2 MGI Mouse Gene Detail - MGI:102759

Symbol

Prss2
Name

serine protease 2
Synonyms

Ta, Tesp4, Try2, TRY8, TRYP

Feature Type

protein coding gene
IDs

MGI:102759
NCBI Gene: 22072
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr6:41498721-41502013 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 19.67 cM
Mapping Data

1 experiment

SNPs within 2kb

218 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102759	protein coding gene	Chr6:41498710-41502013 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030629	protein coding gene	Chr6:40025959-40029251 (+)
A/J	MGP_AJ_G0030602	protein coding gene	Chr6:38283348-38286640 (+)
AKR/J	MGP_AKRJ_G0030527	protein coding gene	Chr6:39521675-39524967 (+)
BALB/cJ	MGP_BALBcJ_G0030612	protein coding gene	Chr6:38491862-38495154 (+)
C3H/HeJ	MGP_C3HHeJ_G0030325	protein coding gene	Chr6:39552594-39555886 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031066	protein coding gene	Chr6:41037990-41041282 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028273	protein coding gene	Chr6:36062733-36065984 (+)
CAST/EiJ	MGP_CASTEiJ_G0029729	protein coding gene	Chr6:39356048-39359320 (+)
CBA/J	MGP_CBAJ_G0030301	protein coding gene	Chr6:42745631-42748923 (+)
DBA/2J	MGP_DBA2J_G0030445	protein coding gene	Chr6:38118212-38121504 (+)
FVB/NJ	MGP_FVBNJ_G0030401	protein coding gene	Chr6:37839608-37842901 (+)
LP/J	MGP_LPJ_G0030533	protein coding gene	Chr6:40038449-40041741 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030435	protein coding gene	Chr6:44980477-44983769 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031096	protein coding gene	Chr6:39498640-39501932 (+)
PWK/PhJ	MGP_PWKPhJ_G0029441	protein coding gene	Chr6:37733070-37736481 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029278	protein coding gene	Chr6:39112646-39115990 (+)
WSB/EiJ	MGP_WSBEiJ_G0029805	protein coding gene	Chr6:39408695-39411983 (+)

Human Ortholog

PRSS2, serine protease 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRSS2, serine protease 2
Synonyms

TRY2, TRY8, TRYP2
Links

HGNC:9483

NCBI Gene ID: 5645

neXtProt AC: NX_P07478

UniProt: P07478
Chr Location

7q34; chr7:142760398-142774564 (+) GRCh38

MGI Vertebrate Homology

Prss2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRSS2
Gene Tree

Prss2

Diseases

1 with human PRSS1 associations

				Human Disease	Mouse Models
				pancreatitis IDs pancreatitis DOID:4989 EFO:0000278 ICD10CM:K85.9 MESH:D010195 NCI:C3306 OMIM:167800 UMLS_CUI:C0030305

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

22
cDNA Data

572
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prss2

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All Sequences

34
RefSeq

3
UniProt

2
CCDS

CCDS20050.1

Ensembl

ENSMUSG00000057163 (Evidence)
NCBI Gene

22072

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057163	Ensembl Gene Model \| MGI Sequence Detail	3293	C57BL/6J	± kb
transcript	ENSMUST00000070380	Ensembl \| MGI Sequence Detail	815	Not Applicable
polypeptide	ENSMUSP00000065393	Ensembl \| MGI Sequence Detail	246	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000027796 trypsin-2

(term hierarchy)
EC

3.4.21.4
InterPro Domains

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR050127 Serine Proteases (Peptidase S1 Family)

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

IPR033116 Serine proteases, trypsin family, serine active site
GlyGen

P07146 1 site, 1 O-linked glycan (1 site)

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All nucleic 573

Genomic 1

cDNA 572

Microarray probesets 4

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MGD-MRK-19664

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 9
Earliest

J:8507 Stevenson BJ, et al., Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes. Nucleic Acids Res. 1986 Nov 11;14(21):8307-30
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Prss2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr55875	Chr6:41498716-41498731 (+)	3 bp
Tssr55876	Chr6:41499797-41499826 (+)	1,091 bp
Tssr55877	Chr6:41500664-41500688 (+)	1,955 bp
Tssr55878	Chr6:41500694-41500705 (+)	1,979 bp
Tssr55879	Chr6:41500708-41500719 (+)	1,993 bp
Tssr55880	Chr6:41500831-41500857 (+)	2,123 bp
Tssr55881	Chr6:41500876-41500892 (+)	2,163 bp
Tssr55882	Chr6:41500922-41500936 (+)	2,208 bp
Tssr55883	Chr6:41500943-41500967 (+)	2,234 bp
Tssr55884	Chr6:41501861-41501871 (+)	3,145 bp
Tssr55885	Chr6:41501957-41501977 (+)	3,246 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24