Ap1m1 MGI Mouse Gene Detail - MGI:102776 - adaptor-related protein complex AP-1, mu subunit 1

Symbol

Ap1m1
Name

adaptor-related protein complex AP-1, mu subunit 1
Synonyms

Adtm1A, AP47, Cltnm, [m]1A, mu1A

Feature Type

protein coding gene
IDs

MGI:102776
NCBI Gene: 11767
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr8:72993862-73011229 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.92 cM
Mapping Data

2 experiments

SNPs within 2kb

435 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102776	protein coding gene	Chr8:72993857-73011230 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033778	protein coding gene	Chr8:72713041-72730245 (+)
A/J	MGP_AJ_G0033760	protein coding gene	Chr8:69776031-69793199 (+)
AKR/J	MGP_AKRJ_G0033687	protein coding gene	Chr8:71840162-71856580 (+)
BALB/cJ	MGP_BALBcJ_G0033754	protein coding gene	Chr8:69903370-69921705 (+)
C3H/HeJ	MGP_C3HHeJ_G0033463	protein coding gene	Chr8:72462584-72479853 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034274	protein coding gene	Chr8:75463606-75487619 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031215	protein coding gene	Chr8:64291984-64308972 (+)
CAST/EiJ	MGP_CASTEiJ_G0032792	protein coding gene	Chr8:71813448-71831786 (+)
CBA/J	MGP_CBAJ_G0033442	protein coding gene	Chr8:78155290-78180434 (+)
DBA/2J	MGP_DBA2J_G0033596	protein coding gene	Chr8:69514959-69532410 (+)
FVB/NJ	MGP_FVBNJ_G0033541	protein coding gene	Chr8:68588567-68605994 (+)
LP/J	MGP_LPJ_G0033685	protein coding gene	Chr8:72806283-72824092 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033585	protein coding gene	Chr8:80666210-80684703 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034291	protein coding gene	Chr8:71888408-71905781 (+)
PWK/PhJ	MGP_PWKPhJ_G0032498	protein coding gene	Chr8:68774758-68792115 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032335	protein coding gene	Chr8:70829396-70848116 (+)
WSB/EiJ	MGP_WSBEiJ_G0032907	protein coding gene	Chr8:72204190-72222812 (+)

Human Ortholog

AP1M1, adaptor related protein complex 1 subunit mu 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AP1M1, adaptor related protein complex 1 subunit mu 1
Synonyms

AP47, CLAPM2, CLTNM, mu1A, MU-1A
Links

HGNC:13667

NCBI Gene ID: 8907

neXtProt AC: NX_Q9BXS5

UniProt: Q9BXS5
Chr Location

19p13.11; chr19:16197854-16245906 (+) GRCh38

MGI Vertebrate Homology

Ap1m1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AP1M1
Protein SuperFamily

Clathrin_mu
Gene Tree

Ap1m1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Targeted

3
Genomic Mutations

1 involving Ap1m1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

Homozygous mutation of this gene results in embryonic lethality around E13.5. Homozygous embryos display hemorrhage of the ventricles and spinal canal.

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All GO Annotations

25
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

16
cDNA Data

155
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ap1m1

ZFIN ap1m1

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All Sequences

62
RefSeq

6
UniProt

7
CCDS

CCDS22411.1

Ensembl

ENSMUSG00000003033 (Evidence)
NCBI Gene

11767

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003033	Ensembl Gene Model \| MGI Sequence Detail	17368	C57BL/6J	± kb
transcript	ENSMUST00000003117	Ensembl \| MGI Sequence Detail	2084	Not Applicable
polypeptide	ENSMUSP00000003117	Ensembl \| MGI Sequence Detail	423	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000004094 AP-1 complex subunit mu-1

(term hierarchy)
PDB

1W63, 4EMZ, 4EN2, 4HMY, 4P6Z, 6CM9, 6CRI, 6D83, 6D84, 6DFF, 7R4H, 7UX3, 8D4C, 8D4D, 8D4E, 8D4F, 8D4G, 8D9R, 8D9S, 8D9T, 8D9U, 8D9V, 8D9W
InterPro Domains

IPR050431 Adaptor complexes medium subunit

IPR036168 AP-2 complex subunit mu, C-terminal superfamily

IPR022775 AP complex, mu/sigma subunit

IPR001392 Clathrin adaptor, mu subunit

IPR018240 Clathrin adaptor, mu subunit, conserved site

IPR011012 Longin-like domain superfamily

IPR028565 Mu homology domain
GlyGen

P35585 1 site, 1 O-linked glycan (1 site)

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All nucleic 156

cDNA 156

Microarray probesets 4

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MGD-MRK-19683, MGI:2142408

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 4
Earliest

J:2826 Nakayama Y, et al., The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast. Eur J Biochem. 1991 Dec 5;202(2):569-74
Latest

J:268942 Fornasiero EF, et al., Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions. Nat Commun. 2018 Oct 12;9(1):4230

TSS for Ap1m1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77958	Chr8:72993878-72993889 (+)	22 bp
Tssr77959	Chr8:72993896-72994025 (+)	99 bp
Tssr77960	Chr8:72994159-72994190 (+)	313 bp
Tssr77961	Chr8:72994192-72994197 (+)	333 bp
Tssr77962	Chr8:73001258-73001276 (+)	7,405 bp
Tssr77963	Chr8:73009605-73009611 (+)	15,746 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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