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Fen1 Gene Detail
Summary
  • Symbol
    Fen1
  • Name
    flap structure specific endonuclease 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102779
    NCBI Gene: 14156
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:10176496-10181533 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 6.54 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    187 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102779
 protein coding gene Chr19:10176496-10181757 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024839
 protein coding gene Chr19:7522646-7527577 (-)
A/J MGP_AJ_G0024807
 protein coding gene Chr19:7006014-7010920 (-)
AKR/J MGP_AKRJ_G0024782
 protein coding gene Chr19:7286314-7291271 (-)
BALB/cJ MGP_BALBcJ_G0024807
 protein coding gene Chr19:7052517-7057684 (-)
C3H/HeJ MGP_C3HHeJ_G0024573
 protein coding gene Chr19:7173384-7178900 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025255
 protein coding gene Chr19:7867770-7874735 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022682
 protein coding gene Chr19:7423998-7428974 (-)
CAST/EiJ MGP_CASTEiJ_G0024046
 protein coding gene Chr19:6834005-6838798 (-)
CBA/J MGP_CBAJ_G0024547
 protein coding gene Chr19:7917204-7922170 (-)
DBA/2J MGP_DBA2J_G0024674
 protein coding gene Chr19:7019679-7024640 (-)
FVB/NJ MGP_FVBNJ_G0024641
 protein coding gene Chr19:7057346-7062286 (-)
LP/J MGP_LPJ_G0024761
 protein coding gene Chr19:7499148-7504083 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024668
 protein coding gene Chr19:7824036-7830048 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025303
 protein coding gene Chr19:7308936-7313878 (-)
PWK/PhJ MGP_PWKPhJ_G0023791
 protein coding gene Chr19:6459997-6464794 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023596
 protein coding gene Chr19:6495526-6501297 (-)
WSB/EiJ MGP_WSBEiJ_G0024108
 protein coding gene Chr19:7191721-7197617 (-)



Homology
more
  • Human Ortholog
    FEN1, flap structure-specific endonuclease 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FEN1, flap structure-specific endonuclease 1
  • Synonyms
    FEN-1, MF1, RAD2
  • Links
    NCBI Gene ID: 2237
    neXtProt AC: NX_P39748
    UniProt: P39748

  • Chr Location
    11q12.2; chr11:61792911-61797238 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 8 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    4 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants do not form an inner cell mass, lack DNA synthesis in blastocyst giant cells and die by embryonic day 9.5. Embryonic day 3.5 blastocysts are hypersensitive to irradiation. Heterozygotes show enhanced adenocarcinoma susceptibility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    15
  • cDNA Data
    144
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024742 Ensembl Gene Model | MGI Sequence Detail 5038 C57BL/6J ±  kb
    transcript ENSMUST00000156291 Ensembl | MGI Sequence Detail 2373 Not Applicable  
    polypeptide ENSMUSP00000117246 Ensembl | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 146
      cDNA 145
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19687, MGI:2147740
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:25230 Harrington JJ, et al., Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair. Genes Dev. 1994 Jun 1;8(11):1344-55
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory