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Bdkrb2 Gene Detail
Summary
  • Symbol
    Bdkrb2
  • Name
    bradykinin receptor, beta 2
  • Synonyms
    B(2), B2, B2R, BK2R, kinin B2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102845
    NCBI Gene: 12062
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:105529485-105561496 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 55.76 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1235 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102845
 protein coding gene Chr12:105529431-105561503 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020091
 protein coding gene Chr12:107443555-107474166 (+)
A/J MGP_AJ_G0020045
 protein coding gene Chr12:103429306-103458951 (+)
AKR/J MGP_AKRJ_G0020021
 protein coding gene Chr12:106426597-106462402 (+)
BALB/cJ MGP_BALBcJ_G0020031
 protein coding gene Chr12:103846608-103876966 (+)
C3H/HeJ MGP_C3HHeJ_G0019833
 protein coding gene Chr12:106852592-106891563 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020476
 protein coding gene Chr12:110754208-110785932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018088
 protein coding gene Chr12:100038379-100068628 (+)
CAST/EiJ MGP_CASTEiJ_G0019375
 protein coding gene Chr12:101660541-101696651 (+)
CBA/J MGP_CBAJ_G0019800
 protein coding gene Chr12:115140525-115175906 (+)
DBA/2J MGP_DBA2J_G0019917
 protein coding gene Chr12:102955307-102985051 (+)
FVB/NJ MGP_FVBNJ_G0019902
 protein coding gene Chr12:101740053-101772361 (+)
LP/J MGP_LPJ_G0019992
 protein coding gene Chr12:107337433-107371853 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019940
 protein coding gene Chr12:118545381-118579526 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020505
 protein coding gene Chr12:105809610-105844118 (+)
PWK/PhJ MGP_PWKPhJ_G0019134
 protein coding gene Chr12:97537333-97579434 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018938
 protein coding gene Chr12:100050893-100080431 (+)
WSB/EiJ MGP_WSBEiJ_G0019432
 protein coding gene Chr12:106774982-106808076 (+)



Homology
more
  • Human Ortholog
    BDKRB2, bradykinin receptor B2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BDKRB2, bradykinin receptor B2
  • Synonyms
    B2R, BK-2, BK2, BKR2, BRB2
  • Links
    NCBI Gene ID: 624
    neXtProt AC: NX_P30411
    UniProt: P30411

  • Chr Location
    14q32.2; chr14:96204679-96244166 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human BDKRB2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 1 allele in 2 genetic backgrounds
    24 phenotypes from multigenic genotypes
    1 images
    105 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are indistinguishable from normal littermates, but bradykinin response is eliminated in ileum, uterus, and cervical ganglia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    20
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021070 Ensembl Gene Model | MGI Sequence Detail 32012 C57BL/6J ±  kb
    transcript ENSMUST00000001652 Ensembl | MGI Sequence Detail 3792 Not Applicable  
    polypeptide ENSMUSP00000001652 Ensembl | MGI Sequence Detail 392 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 10
      cDNA 14
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19754
    References
    more
    • Summaries
      All 158
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 105
    • Earliest
      J:16469 McIntyre P, et al., Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity [published erratum appears in Mol Pharmacol 1994 Mar;45(3):561]. Mol Pharmacol. 1993 Aug;44(2):346-55
    • Latest
      J:350097 Franco TM, et al., Effects of Bradykinin B2 Receptor Ablation from Tyrosine Hydroxylase Cells on Behavioral and Motor Aspects in Male and Female Mice. Int J Mol Sci. 2024 Jan 25;25(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory