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Ube2a Gene Detail
Summary
  • Symbol
    Ube2a
  • Name
    ubiquitin-conjugating enzyme E2A
  • Synonyms
    HHR6A, HR6A
  • Feature Type
    protein coding gene
  • IDs
    MGI:102959
    NCBI Gene: 22209
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:36137948-36147875 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 21.28 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    261 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102959
 protein coding gene ChrX:36064828-36147875 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035626
 protein coding gene ChrX:31809807-31819696 (+)
A/J MGP_AJ_G0035603
 protein coding gene ChrX:31862047-31875790 (+)
AKR/J MGP_AKRJ_G0035536
 protein coding gene ChrX:32586659-32597485 (+)
BALB/cJ MGP_BALBcJ_G0035596
 protein coding gene ChrX:31606523-31616702 (+)
C3H/HeJ MGP_C3HHeJ_G0035314
 protein coding gene ChrX:32123375-32134449 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036132
 protein coding gene ChrX:32440748-32455464 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032994
 protein coding gene ChrX:30094609-30104870 (+)
CAST/EiJ MGP_CASTEiJ_G0034604
 protein coding gene ChrX:20278373-20288547 (+)
CBA/J MGP_CBAJ_G0035283
 protein coding gene ChrX:33294463-33304261 (+)
DBA/2J MGP_DBA2J_G0035434
 protein coding gene ChrX:31694499-31704635 (+)
FVB/NJ MGP_FVBNJ_G0035381
 protein coding gene ChrX:31466190-31476027 (+)
LP/J MGP_LPJ_G0035516
 protein coding gene ChrX:32154168-32167240 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035425
 protein coding gene ChrX:33752388-33764181 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036139
 protein coding gene ChrX:31773599-31783862 (+)
PWK/PhJ MGP_PWKPhJ_G0034306
 protein coding gene ChrX:19742014-19752301 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034147
 protein coding gene ChrX:20760487-20775507 (+)
WSB/EiJ MGP_WSBEiJ_G0034740
 protein coding gene ChrX:31570155-31584836 (+)



Homology
more
  • Human Ortholog
    UBE2A, ubiquitin conjugating enzyme E2 A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBE2A, ubiquitin conjugating enzyme E2 A
  • Synonyms
    HHR6A, MRXS30, MRXSN, RAD6A, UBC2
  • Links
    NCBI Gene ID: 7319
    neXtProt AC: NX_P49459
    UniProt: P49459

  • Chr Location
    Xq24; chrX:119474802-119591083 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human UBE2A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in decreased body weight. Females are infertile while males show partial prenatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    55
  • cDNA Data
    87
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22209 NCBI Gene Model | MGI Sequence Detail 9928 C57BL/6J ±  kb
    transcript NM_019668 RefSeq | MGI Sequence Detail 1746 C57BL/6  
    polypeptide Q9Z255 UniProt | EBI | MGI Sequence Detail 152 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      cDNA 88
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-23795
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 6
      Gene Ontology 15
      Phenotypes 10
    • Earliest
      J:12580 Koken MH, et al., Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. Genomics. 1992 Mar;12(3):447-53
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory