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Klra8 Gene Detail
Summary
  • Symbol
    Klra8
  • Name
    killer cell lectin-like receptor, subfamily A, member 8
  • Synonyms
    Cmv-1, Cmv1, Ly49h, Ly49u129
  • Feature Type
    protein coding gene
  • IDs
    MGI:102968
    NCBI Gene: 16639
  • Member of
    Klra cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:130092189-130106861 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.44 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    156 from dbSNP Build 142
  • Strain Annotations
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102968
 protein coding gene Chr6:130092189-130106861 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0031335
 protein coding gene Chr6:128561958-128834827 (-)
AKR/J MGP_AKRJ_G0031263
 protein coding gene Chr6:132060920-132332859 (-)
BALB/cJ MGP_BALBcJ_G0031342
 protein coding gene Chr6:128457097-128590071 (-)
C3H/HeJ MGP_C3HHeJ_G0031065
 protein coding gene Chr6:132284718-132556950 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031184
 protein coding gene Chr6:127498504-127802038 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0031265
 protein coding gene Chr6:133877403-134212091 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0031837
 protein coding gene Chr6:132311267-132327025 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most mouse strains other than C57BL/6 and C57BL/10 lack this gene and this correlates with an increased susceptiblity to CMV infection. A congenic strain in which the CMV resistant allele from C57BL/6 mice has been introduced in the BALB/c background shows high susceptibility to malarial infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16639 NCBI Gene Model | MGI Sequence Detail 14673 C57BL/6J ±  kb
    transcript NM_001101620 RefSeq | MGI Sequence Detail 1178 Not Specified  
    polypeptide Q60682 UniProt | EBI | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 20
      cDNA 5
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2030, MGD-MRK-2031, MGD-MRK-23805, MGI:88429
    References
    more
    • Summaries
      All 104
      Gene Ontology 5
      Phenotypes 56
    • Earliest
      J:10460 Scalzo AA, et al., Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen. J Exp Med. 1990 May 1;171(5):1469-83
    • Latest
      J:351157 Vetters J, et al., Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection. iScience. 2023 Dec 15;26(12):108570
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory