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E2f4 Gene Detail
Summary
  • Symbol
    E2f4
  • Name
    E2F transcription factor 4
  • Synonyms
    2010111M04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:103012
    NCBI Gene: 104394
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106024295-106032002 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103012
 protein coding gene Chr8:106024295-106032002 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034037
 protein coding gene Chr8:107562882-107571517 (+)
A/J MGP_AJ_G0034018
 protein coding gene Chr8:103275336-103283101 (+)
AKR/J MGP_AKRJ_G0033944
 protein coding gene Chr8:106259290-106266979 (+)
BALB/cJ MGP_BALBcJ_G0034011
 protein coding gene Chr8:103451917-103460123 (+)
C3H/HeJ MGP_C3HHeJ_G0033723
 protein coding gene Chr8:107006620-107017960 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034531
 protein coding gene Chr8:111512108-111520355 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031473
 protein coding gene Chr8:96425033-96432483 (+)
CAST/EiJ MGP_CASTEiJ_G0033049
 protein coding gene Chr8:106505734-106513258 (+)
CBA/J MGP_CBAJ_G0033696
 protein coding gene Chr8:115109374-115117511 (+)
DBA/2J MGP_DBA2J_G0033851
 protein coding gene Chr8:102620410-102628111 (+)
FVB/NJ MGP_FVBNJ_G0033797
 protein coding gene Chr8:101544404-101552561 (+)
LP/J MGP_LPJ_G0033942
 protein coding gene Chr8:107773802-107781460 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033840
 protein coding gene Chr8:118324864-118334767 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034549
 protein coding gene Chr8:106234290-106242471 (+)
PWK/PhJ MGP_PWKPhJ_G0032750
 protein coding gene Chr8:102007014-102015345 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032591
 protein coding gene Chr8:104911069-104918285 (+)
WSB/EiJ MGP_WSBEiJ_G0033165
 protein coding gene Chr8:106887695-106895374 (+)



Homology
more
  • Human Ortholog
    E2F4, E2F transcription factor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    E2F4, E2F transcription factor 4
  • Synonyms
    E2F-4
  • Links
    NCBI Gene ID: 1874
    neXtProt AC: NX_Q16254
    UniProt: Q16254

  • Chr Location
    16q22.1; chr16:67192155-67198918 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with E2f4 mouse models; 1 with human E2F4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 3 alleles in 4 genetic backgrounds
    14 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die postnatally of an increased susceptibility to bacterial infection and exhibit craniofacial defects, erythroid abnormalities, and growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1091
  • Tissues
    275
  • cDNA Data
    71
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104394 NCBI Gene Model | MGI Sequence Detail 7708 C57BL/6J ±  kb
    transcript NM_148952 RefSeq | MGI Sequence Detail 2024 FVB/N  
    polypeptide Q8R0K9 UniProt | EBI | MGI Sequence Detail 410 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 71
      Primer pair 7
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23849, MGI:1919312, MGI:2142532
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 30
      Diseases 1
      Gene Ontology 16
      Phenotypes 30
    • Earliest
      J:21634 Beijersbergen RL, et al., E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev. 1994 Nov 15;8(22):2680-90
    • Latest
      J:353480 Huang S, et al., Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis. Nat Commun. 2024 Aug 15;15(1):7019
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory