About   Help   FAQ
Reln Gene Detail
Summary
  • Symbol
    Reln
  • Name
    reelin
  • Feature Type
    protein coding gene
  • IDs
    MGI:103022
    NCBI Gene: 19699
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:22089452-22549700 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 9.98 cM, cytoband A3-B1
  • Mapping Data
    29 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13118 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103022
 protein coding gene Chr5:22089452-22549703 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029326
 protein coding gene Chr5:19470485-19937042 (-)
A/J MGP_AJ_G0029291
 protein coding gene Chr5:18827726-19294099 (-)
AKR/J MGP_AKRJ_G0029242
 protein coding gene Chr5:19550896-20023364 (-)
BALB/cJ MGP_BALBcJ_G0029303
 protein coding gene Chr5:19264102-19722346 (-)
C3H/HeJ MGP_C3HHeJ_G0029022
 protein coding gene Chr5:19623634-20097891 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029756
 protein coding gene Chr5:20879604-21365242 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026995
 protein coding gene Chr5:16884756-17323564 (-)
CAST/EiJ MGP_CASTEiJ_G0028434
 protein coding gene Chr5:18959829-19433537 (-)
CBA/J MGP_CBAJ_G0028989
 protein coding gene Chr5:21123931-21632446 (-)
DBA/2J MGP_DBA2J_G0029141
 protein coding gene Chr5:19113072-19573000 (-)
FVB/NJ MGP_FVBNJ_G0029099
 protein coding gene Chr5:18516531-18972019 (-)
LP/J MGP_LPJ_G0029225
 protein coding gene Chr5:19878398-20337809 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029127
 protein coding gene Chr5:22383401-22870716 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029789
 protein coding gene Chr5:19204126-19649447 (-)
PWK/PhJ MGP_PWKPhJ_G0028157
 protein coding gene Chr5:18170825-18622228 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027990
 protein coding gene Chr5:18575683-19054603 (-)
WSB/EiJ MGP_WSBEiJ_G0028514
 protein coding gene Chr5:19271342-19732417 (-)



Homology
more
  • Human Ortholog
    RELN, reelin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RELN, reelin
  • Synonyms
    ETL7, LIS2, PRO1598, RL
  • Links
    NCBI Gene ID: 5649
    neXtProt AC: NX_P78509
    UniProt: P78509

  • Chr Location
    7q22.1; chr7:103471381-103989658 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Reln mouse models; 3 with human RELN associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    77 phenotypes from 15 alleles in 22 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    359 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for most spontaneous or ENU-induced mutations show impaired righting responses, ataxia, tremors, and cerebellum and hippocampus abnormalities. Some mutants show postnatal or premature death and decreased body size while others have abnormal retinas or olfactory bulbs or infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    103
  • GO References
    48
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1908
  • Tissues
    481
  • cDNA Data
    124
  • Literature Summary
    487
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042453 Ensembl Gene Model | MGI Sequence Detail 460249 C57BL/6J ±  kb
    transcript ENSMUST00000161356 Ensembl | MGI Sequence Detail 11699 Not Applicable  
    polypeptide ENSMUSP00000124052 Ensembl | MGI Sequence Detail 3461 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 204
      Genomic 24
      cDNA 132
      Primer pair 20
      Other 28

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13895, MGD-MRK-23859
    References
    more
    • Summaries
      All 916
      Developmental Gene Expression 487
      Diseases 3
      Gene Ontology 48
      Phenotypes 359
    • Earliest
      J:13038 Falconer DS, Two new mutants, "trembler" and "reeler," with neurological actions in the house mouse. J Genet. 1951;50(2):192-201
    • Latest
      J:357552 McRae HM, et al., Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Borjeson-Forssman-Lehmann intellectual disability syndrome. PLoS Genet. 2024 Oct;20(10):e1011428
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory