Whl Gene Detail

Summary

• Symbol
  Whl
• Name
  wheels

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:103024
  NCBI Gene: 109553
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr4:8426721-9574055 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 4, Syntenic
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  20 phenotypes from 1 allele in 2 genetic backgrounds
  3 phenotype references
  

• All Mutations and Alleles
  1
• Chemically induced (ENU)
  1
• Find Mice (IMSR)
  0 strains or lines available

Heterozygotes show altered circadian activity, circling behavior with inner ear defects and abnormal response to light. Homozygous embryos show retarded growth, impaired hindbrain development, abnormal vascular branching and die at embryonic day 10.5-11.5.

Sequences &
Gene Models

• NCBI Gene
  109553

Other
Accession IDs

MGD-MRK-23861

References

• Summaries
  All 5

  Phenotypes 3
• Earliest
  J:24933 Nolan PM, et al., Heterozygosity mapping of partially congenic lines: mapping of a semidominant neurological mutation, Wheels (Whl), on mouse chromosome 4. Genetics. 1995 May;140(1):245-54
• Latest
  J:93173 Pau H, et al., Characterization of a new mouse mutant, flouncer, with a balance defect and inner ear malformation. Otol Neurotol. 2004 Sep;25(5):707-13