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Stat5a Gene Detail
Summary
  • Symbol
    Stat5a
  • Name
    signal transducer and activator of transcription 5A
  • Synonyms
    STAT5
  • Feature Type
    protein coding gene
  • IDs
    MGI:103036
    NCBI Gene: 20850
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100750177-100775995 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.77 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    697 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103036
 protein coding gene Chr11:100750177-100775995 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019172
 protein coding gene Chr11:103639177-103668580 (+)
A/J MGP_AJ_G0019140
 protein coding gene Chr11:99311441-99339691 (+)
AKR/J MGP_AKRJ_G0019109
 protein coding gene Chr11:102400424-102426008 (+)
BALB/cJ MGP_BALBcJ_G0019114
 protein coding gene Chr11:99797467-99826085 (+)
C3H/HeJ MGP_C3HHeJ_G0018923
 protein coding gene Chr11:102560630-102595497 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019563
 protein coding gene Chr11:106846037-106876362 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017189
 protein coding gene Chr11:96732179-96757921 (+)
CAST/EiJ MGP_CASTEiJ_G0018477
 protein coding gene Chr11:103548501-103577839 (+)
CBA/J MGP_CBAJ_G0018892
 protein coding gene Chr11:111312274-111346717 (+)
DBA/2J MGP_DBA2J_G0019004
 protein coding gene Chr11:98849065-98873994 (+)
FVB/NJ MGP_FVBNJ_G0018994
 protein coding gene Chr11:98389456-98415561 (+)
LP/J MGP_LPJ_G0019073
 protein coding gene Chr11:104192911-104225548 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019025
 protein coding gene Chr11:110883338-110920313 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019601
 protein coding gene Chr11:102713331-102741858 (+)
PWK/PhJ MGP_PWKPhJ_G0018240
 protein coding gene Chr11:99894405-99920775 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018032
 protein coding gene Chr11:102457408-102483628 (+)
WSB/EiJ MGP_WSBEiJ_G0018526
 protein coding gene Chr11:102707271-102739652 (+)



Homology
more
  • Human Ortholog
    STAT5A, signal transducer and activator of transcription 5A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAT5A, signal transducer and activator of transcription 5A
  • Synonyms
    MGF, STAT5
  • Links
    NCBI Gene ID: 6776
    neXtProt AC: NX_P42229
    UniProt: P42229

  • Chr Location
    17q21.2; chr17:42287439-42311943 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human STAT5A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 4 alleles in 7 genetic backgrounds
    80 phenotypes from multigenic genotypes
    206 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are reduced in size and display abnormalities in both mammary gland structure and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    123
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1099
  • Tissues
    245
  • cDNA Data
    69
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20850 NCBI Gene Model | MGI Sequence Detail 25819 C57BL/6J ±  kb
    transcript NM_011488 RefSeq | MGI Sequence Detail 3910 C57BL/6  
    polypeptide P42230 UniProt | EBI | MGI Sequence Detail 793 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000002091 signal transducer and activator of transcription 5a
      (term hierarchy)
    • PDB
      1Y1U
    • InterPro Domains
      IPR008967 p53-like transcription factor, DNA-binding domain superfamily
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR048988 Signal transducer and activator of transcription, linker domain
      IPR046994 STAT5a/5b, coiled-coil domain
      IPR035858 STAT5a/5b, DNA-binding domain
      IPR013800 STAT transcription factor, all-alpha domain
      IPR015988 STAT transcription factor, coiled coil
      IPR013801 STAT transcription factor, DNA-binding
      IPR012345 STAT transcription factor, DNA-binding, N-terminal
      IPR036535 STAT transcription factor, N-terminal domain superfamily
      IPR013799 STAT transcription factor, protein interaction
      IPR001217 Transcription factor STAT
    • GlyGen
      P42230 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 70
      Primer pair 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23874, MGI:2144052
    References
    more
    • Summaries
      All 451
      Developmental Gene Expression 35
      Gene Ontology 31
      Phenotypes 206
    • Earliest
      J:24359 Mui AL, et al., Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 1995 Mar 15;14(6):1166-75
    • Latest
      J:353834 Lin JX, et al., Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation. Nat Commun. 2024 Aug 27;15(1):7372
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory