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Stat4 Gene Detail
Summary
  • Symbol
    Stat4
  • Name
    signal transducer and activator of transcription 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:103062
    NCBI Gene: 20849
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:52026307-52146348 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 26.67 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3790 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103062
 protein coding gene Chr1:52026265-52146348 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016005
 protein coding gene Chr1:51489328-51615367 (+)
A/J MGP_AJ_G0015987
 protein coding gene Chr1:49767891-49888040 (+)
AKR/J MGP_AKRJ_G0015943
 protein coding gene Chr1:50813358-50940648 (+)
BALB/cJ MGP_BALBcJ_G0015944
 protein coding gene Chr1:49579658-49702948 (+)
C3H/HeJ MGP_C3HHeJ_G0015776
 protein coding gene Chr1:51217508-51346069 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016395
 protein coding gene Chr1:53664175-53788748 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014129
 protein coding gene Chr1:41969035-42087567 (-)
CAST/EiJ MGP_CASTEiJ_G0015357
 protein coding gene Chr1:50694650-50824019 (+)
CBA/J MGP_CBAJ_G0015747
 protein coding gene Chr1:55086923-55219958 (+)
DBA/2J MGP_DBA2J_G0015848
 protein coding gene Chr1:49020524-49139372 (+)
FVB/NJ MGP_FVBNJ_G0015850
 protein coding gene Chr1:48486030-48604398 (+)
LP/J MGP_LPJ_G0015919
 protein coding gene Chr1:51972149-52112981 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015870
 protein coding gene Chr1:58117357-58249472 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016443
 protein coding gene Chr1:50944377-51070511 (+)
PWK/PhJ MGP_PWKPhJ_G0015143
 protein coding gene Chr1:48898082-49020483 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014923
 protein coding gene Chr1:50599081-50725288 (+)
WSB/EiJ MGP_WSBEiJ_G0015420
 protein coding gene Chr1:50758577-50883154 (+)



Homology
more
  • Human Ortholog
    STAT4, signal transducer and activator of transcription 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAT4, signal transducer and activator of transcription 4
  • Synonyms
    DPMC, SLEB11
  • Links
    NCBI Gene ID: 6775
    neXtProt AC: NX_Q14765
    UniProt: Q14765

  • Chr Location
    2q32.2-q32.3; chr2:191029576-191178435 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Stat4 mouse models; 18 with human STAT4 associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 4 alleles in 8 genetic backgrounds
    8 phenotypes from multigenic genotypes
    231 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to altered cytokine production of T-cells, impaired IL-12 responses, enhanced Th2 cell development, decreased susceptibility to autoimmune diabetes, altered NK cell responses during viral infection, and increased susceptibility to Salmonella infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    68
  • cDNA Data
    41
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062939 Ensembl Gene Model | MGI Sequence Detail 120042 C57BL/6J ±  kb
    transcript ENSMUST00000027277 Ensembl | MGI Sequence Detail 2982 Not Applicable  
    polypeptide ENSMUSP00000027277 Ensembl | MGI Sequence Detail 748 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000002090 signal transducer and activator of transcription 4
      (term hierarchy)
    • PDB
      1BGF
    • InterPro Domains
      IPR008967 p53-like transcription factor, DNA-binding domain superfamily
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR046991 Signal transducer and activator of transcription 4 , coiled-coil domain
      IPR029839 Signal transducer and activator of transcription 4, DNA-binding domain
      IPR048988 Signal transducer and activator of transcription, linker domain
      IPR035856 STAT4, SH2 domain
      IPR013800 STAT transcription factor, all-alpha domain
      IPR015988 STAT transcription factor, coiled coil
      IPR013801 STAT transcription factor, DNA-binding
      IPR012345 STAT transcription factor, DNA-binding, N-terminal
      IPR036535 STAT transcription factor, N-terminal domain superfamily
      IPR013799 STAT transcription factor, protein interaction
      IPR001217 Transcription factor STAT
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 41
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23924
    References
    more
    • Summaries
      All 326
      Developmental Gene Expression 11
      Diseases 3
      Gene Ontology 14
      Phenotypes 231
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:359107 Mangani D, et al., Transcription factor TCF1 binds to RORgammat and orchestrates a regulatory network that determines homeostatic Th17 cell state. Immunity. 2024 Oct 15;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory