Pctr2 QTL Detail

Summary

• Symbol
  Pctr2
• Name
  plasmacytoma resistance 2
• Synonyms
  Pcts3

• Feature Type
  QTL
• IDs
  MGI:103068
  NCBI Gene: 104290
• Candidate Genes
  2 Genes

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 4, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  104290

Other
Accession IDs

MGD-MRK-16286, MGD-MRK-23930

References

• Summaries
  All 7

  Phenotypes 1
• Earliest
  J:16958 Potter M, et al., Identification of two genes on chromosome 4 that determine resistance to plasmacytoma induction in mice. Cancer Res. 1994 Feb 15;54(4):969-75
• Latest
  J:86978 Bliskovsky V, et al., Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14982-7

Candidate Genes for Pctr2:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Fbxo6	Chr4:148230173-148236592 (-)	J:86978	A Congenic strain between BALB/cAn and DBA/2N ( C.D2-Fv1B) was constructed to exclude Xmv8 and Xmv44 from consideration as candidates for Pctr2. Using C.D2-Fv1B the authors were able to refine the region containing Pctr2 to D4Mit310 and D4Mit129. Further a region 86 kb distal of Fbxo6b was identified as the proximal interval of Pctr2. Using the MIT markers BAC clones were isolated for the purpose of identifying polymorphisms in genes that could be potential candidates for Pctr2. Polymorphisms between BALB/cAn and DBA/2N resulting in AA changes in the Frap1 genes are suggestive as causative of the Pctr2 phenotype.
Mtor	Chr4:148533068-148642140 (+)	J:86978	A Congenic strain between BALB/cAn and DBA/2N ( C.D2-Fv1B) was constructed to exclude Xmv8 and Xmv44 from consideration as candidates for Pctr2. Using C.D2-Fv1B the authors were able to refine the region containing Pctr2 to D4Mit310 and D4Mit129. Further a region 86 kb distal of Fbxo6b was identified as the proximal interval of Pctr2. Using the MIT markers BAC clones were isolated for the purpose of identifying polymorphisms in genes that could be potential candidates for Pctr2. Polymorphisms between BALB/cAn and DBA/2N resulting in AA changes in the Frap1 genes are suggestive as causative of the Pctr2 phenotype.