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Vdr Gene Detail
Summary
  • Symbol
    Vdr
  • Name
    vitamin D (1,25-dihydroxyvitamin D3) receptor
  • Synonyms
    Nr1i1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103076
    NCBI Gene: 22337
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:97752308-97806177 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 53.85 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1631 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103076
 protein coding gene Chr15:97752306-97808511 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022281
 protein coding gene Chr15:99531498-99591729 (-)
A/J MGP_AJ_G0022240
 protein coding gene Chr15:95596983-95653447 (-)
AKR/J MGP_AKRJ_G0022215
 protein coding gene Chr15:98477292-98536172 (-)
BALB/cJ MGP_BALBcJ_G0022246
 protein coding gene Chr15:95818535-95874924 (-)
C3H/HeJ MGP_C3HHeJ_G0022016
 protein coding gene Chr15:98556764-98614429 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022691
 protein coding gene Chr15:103202444-103263366 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020217
 protein coding gene Chr15:91540998-91597511 (-)
CAST/EiJ MGP_CASTEiJ_G0021538
 protein coding gene Chr15:99428003-99486512 (-)
CBA/J MGP_CBAJ_G0021983
 protein coding gene Chr15:106659610-106718597 (-)
DBA/2J MGP_DBA2J_G0022110
 protein coding gene Chr15:95044511-95100396 (-)
FVB/NJ MGP_FVBNJ_G0022089
 protein coding gene Chr15:94037177-94093796 (-)
LP/J MGP_LPJ_G0022181
 protein coding gene Chr15:99641538-99702745 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022109
 protein coding gene Chr15:110781397-110840378 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022706
 protein coding gene Chr15:98625739-98683833 (-)
PWK/PhJ MGP_PWKPhJ_G0021279
 protein coding gene Chr15:95145268-95202140 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021113
 protein coding gene Chr15:98400697-98461552 (-)
WSB/EiJ MGP_WSBEiJ_G0021587
 protein coding gene Chr15:99148678-99207192 (-)



Homology
more
  • Human Ortholog
    VDR, vitamin D receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VDR, vitamin D receptor
  • Synonyms
    NR1I1, PPP1R163
  • Links
    NCBI Gene ID: 7421
    neXtProt AC: NX_P11473
    UniProt: P11473

  • Chr Location
    12q13.11; chr12:47841537-47943048 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Vdr mouse models; 45 with human VDR associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
 View 1 model
      
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    161 phenotypes from 11 alleles in 17 genetic backgrounds
    36 phenotypes from multigenic genotypes
    3 images
    340 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants fail to thrive after weaning and may exhibit excess mortality. Postweaning mutant mice develop alopecia, hypocalcemia, infertility, and rickets. Mutant females exhibit uterine hypoplasia with impaired follicular development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    107
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1011
  • Tissues
    269
  • cDNA Data
    12
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22337 NCBI Gene Model | MGI Sequence Detail 53870 C57BL/6J ±  kb
    transcript NM_009504 RefSeq | MGI Sequence Detail 4354 C57BL/6  
    polypeptide P48281 UniProt | EBI | MGI Sequence Detail 422 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 2
      cDNA 12
      Primer pair 9
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-23940
    References
    more
    • Summaries
      All 466
      Developmental Gene Expression 30
      Diseases 6
      Gene Ontology 19
      Phenotypes 340
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:346896 Cong J, et al., Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8(+) T cell effector functions. Immunity. 2024 Apr 9;57(4):876-889.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory