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Pdpn Gene Detail
Summary
  • Symbol
    Pdpn
  • Name
    podoplanin
  • Synonyms
    Gp38, OTS-8, PA2.26, RANDAM-2, T1a, T1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:103098
    NCBI Gene: 14726
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:142994001-143026134 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 77.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    318 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103098
 protein coding gene Chr4:142993979-143026134 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029066
 protein coding gene Chr4:146471936-146514758 (-)
A/J MGP_AJ_G0029026
 protein coding gene Chr4:140101395-140134909 (-)
AKR/J MGP_AKRJ_G0028978
 protein coding gene Chr4:144136931-144168645 (-)
BALB/cJ MGP_BALBcJ_G0029050
 protein coding gene Chr4:140766290-140802259 (-)
C3H/HeJ MGP_C3HHeJ_G0028764
 protein coding gene Chr4:144521729-144554582 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029491
 protein coding gene Chr4:151513477-151549400 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026761
 protein coding gene Chr4:132948110-132981158 (-)
CAST/EiJ MGP_CASTEiJ_G0028196
 protein coding gene Chr4:142811212-142855839 (-)
CBA/J MGP_CBAJ_G0028728
 protein coding gene Chr4:156053307-156099487 (-)
DBA/2J MGP_DBA2J_G0028878
 protein coding gene Chr4:140448029-140481540 (-)
FVB/NJ MGP_FVBNJ_G0028845
 protein coding gene Chr4:139611727-139648497 (-)
LP/J MGP_LPJ_G0028977
 protein coding gene Chr4:146507050-146550480 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028871
 protein coding gene Chr4:159698737-159748732 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029529
 protein coding gene Chr4:144683720-144718751 (-)
PWK/PhJ MGP_PWKPhJ_G0027918
 protein coding gene Chr4:137358515-137393804 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027741
 protein coding gene Chr4:140501461-140542519 (-)
WSB/EiJ MGP_WSBEiJ_G0028274
 protein coding gene Chr4:144961538-145019002 (-)



Homology
more
  • Human Ortholog
    PDPN, podoplanin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDPN, podoplanin
  • Synonyms
    AGGRUS, D2-40, GP36, Gp38, GP40, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A
  • Links
    NCBI Gene ID: 10630
    neXtProt AC: NX_Q86YL7
    UniProt: Q86YL7

  • Chr Location
    1p36.21; chr1:13583465-13617957 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 6 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null neonates die exhibiting respiratory failure. Mice homozygous for another knock-out allele exhibit blood-lymph mixing and intestinal edema.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1192
  • Tissues
    167
  • cDNA Data
    28
  • Literature Summary
    276
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028583 Ensembl Gene Model | MGI Sequence Detail 32134 C57BL/6J ±  kb
    transcript ENSMUST00000030317 Ensembl | MGI Sequence Detail 1817 Not Applicable  
    polypeptide ENSMUSP00000030317 Ensembl | MGI Sequence Detail 172 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 28
      Primer pair 12

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-23962
    References
    more
    • Summaries
      All 373
      Developmental Gene Expression 276
      Gene Ontology 19
      Phenotypes 50
    • Earliest
      J:27387 Nose K, et al., Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells. Cell Growth Differ. 1990 Nov;1(11):511-8
    • Latest
      J:354188 Vallecillo-Garcia P, et al., Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation. Development. 2024 Sep 1;151(17):dev202747
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory