Btn1a1 MGI Mouse Gene Detail - MGI:103118 - butyrophilin, subfamily 1, member A1

Symbol

Btn1a1
Name

butyrophilin, subfamily 1, member A1
Synonyms

Btn

Feature Type

protein coding gene
IDs

MGI:103118
NCBI Gene: 12231
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:23641162-23650071 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 9.72 cM
Mapping Data

7 experiments

SNPs within 2kb

290 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103118	protein coding gene	Chr13:23641154-23650084 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020342	protein coding gene	Chr13:20863267-20872199 (-)
A/J	MGP_AJ_G0020299	protein coding gene	Chr13:20493517-20502505 (-)
AKR/J	MGP_AKRJ_G0020271	protein coding gene	Chr13:20733989-20742901 (-)
BALB/cJ	MGP_BALBcJ_G0020285	protein coding gene	Chr13:20484635-20493544 (-)
C3H/HeJ	MGP_C3HHeJ_G0020094	protein coding gene	Chr13:20816360-20825257 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020730	protein coding gene	Chr13:21624111-21633032 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018314	protein coding gene	Chr13:19294942-19304013 (-)
CAST/EiJ	MGP_CASTEiJ_G0019616	protein coding gene	Chr13:20502607-20511524 (-)
CBA/J	MGP_CBAJ_G0020045	protein coding gene	Chr13:22463644-22472903 (-)
DBA/2J	MGP_DBA2J_G0020171	protein coding gene	Chr13:20063360-20072252 (-)
FVB/NJ	MGP_FVBNJ_G0020159	protein coding gene	Chr13:19682653-19691560 (-)
LP/J	MGP_LPJ_G0020244	protein coding gene	Chr13:21189375-21198304 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020189	protein coding gene	Chr13:22782393-22792221 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020760	protein coding gene	Chr13:20586761-20595656 (-)
PWK/PhJ	MGP_PWKPhJ_G0019371	protein coding gene	Chr13:20050622-20059737 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019182	protein coding gene	Chr13:19384259-19394452 (-)
WSB/EiJ	MGP_WSBEiJ_G0019672	protein coding gene	Chr13:20715776-20724662 (-)

Human Ortholog

BTN1A1, butyrophilin subfamily 1 member A1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BTN1A1, butyrophilin subfamily 1 member A1
Synonyms

BT, BTN, BTN1
Links

HGNC:1135

NCBI Gene ID: 696

neXtProt AC: NX_Q13410

UniProt: Q13410
Chr Location

6p22.2; chr6:26500303-26510425 (+) GRCh38

MGI Vertebrate Homology

Btn1a1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BTN1A1
Gene Tree

Btn1a1

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Btn1a1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display impaired lactation and abnormal lipid accumulation in the mammary gland.

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

14
cDNA Data

53
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BTN1A1

Xenbase btn1a1

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All Sequences

41
RefSeq

4
UniProt

4
CCDS

CCDS26339.1

Ensembl

ENSMUSG00000000706 (Evidence)
NCBI Gene

12231

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000706	Ensembl Gene Model \| MGI Sequence Detail	8910	C57BL/6J	± kb
transcript	ENSMUST00000041674	Ensembl \| MGI Sequence Detail	3423	Not Applicable
polypeptide	ENSMUSP00000041013	Ensembl \| MGI Sequence Detail	524	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004848 butyrophilin subfamily 1 member A1

(term hierarchy)
InterPro Domains

IPR001870 B30.2/SPRY domain

IPR043136 B30.2/SPRY domain superfamily

IPR037958 Butyrophilin subfamily 1/2, SPRY/PRY domain

IPR003879 Butyrophylin-like, SPRY domain

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR050504 Immunoglobulin superfamily BTN/MOG domain-containing protein

IPR013106 Immunoglobulin V-set domain

IPR006574 SPRY-associated

IPR003877 SPRY domain
GlyGen

Q62556 2 sites

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All nucleic 63

Genomic 5

cDNA 55

Other 3

Microarray probesets 5

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MGD-MRK-23982

Summaries

All 52

Developmental Gene Expression 5

Gene Ontology 3

Phenotypes 18
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:321944 Jeong J, et al., The butyrophilin 1a1 knockout mouse revisited: Ablation of Btn1a1 leads to concurrent cell death and renewal in the mammary epithelium during lactation. FASEB Bioadv. 2021 Dec;3(12):971-997

TSS for Btn1a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121709	Chr13:23650065-23650084 (-)	-4 bp
Tssr121708	Chr13:23650042-23650049 (-)	25 bp
Tssr121707	Chr13:23650032-23650040 (-)	35 bp
Tssr121706	Chr13:23650009-23650029 (-)	52 bp
Tssr121705	Chr13:23649938-23649943 (-)	130 bp
Tssr121704	Chr13:23646963-23646965 (-)	3,107 bp
Tssr121703	Chr13:23642607-23642609 (-)	7,463 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24