Barx1 MGI Mouse Gene Detail - MGI:103124

Symbol

Barx1
Name

BarH-like homeobox 1

Feature Type

protein coding gene
IDs

MGI:103124
NCBI Gene: 12022
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr13:48816512-48819983 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 24.90 cM
Mapping Data

1 experiment

SNPs within 2kb

119 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103124	protein coding gene	Chr13:48816474-48819983 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020526	protein coding gene	Chr13:47582972-47586481 (+)
A/J	MGP_AJ_G0020480	protein coding gene	Chr13:45907648-45911157 (+)
AKR/J	MGP_AKRJ_G0020457	protein coding gene	Chr13:47192591-47196100 (+)
BALB/cJ	MGP_BALBcJ_G0020476	protein coding gene	Chr13:46120589-46124098 (+)
C3H/HeJ	MGP_C3HHeJ_G0020275	protein coding gene	Chr13:47021337-47024846 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020909	protein coding gene	Chr13:49024108-49027617 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018494	protein coding gene	Chr13:43903866-43907403 (+)
CAST/EiJ	MGP_CASTEiJ_G0019790	protein coding gene	Chr13:47012627-47016122 (+)
CBA/J	MGP_CBAJ_G0020236	protein coding gene	Chr13:51040869-51044378 (+)
DBA/2J	MGP_DBA2J_G0020358	protein coding gene	Chr13:45435445-45438954 (+)
FVB/NJ	MGP_FVBNJ_G0020337	protein coding gene	Chr13:44946207-44949716 (+)
LP/J	MGP_LPJ_G0020433	protein coding gene	Chr13:47809097-47812606 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020366	protein coding gene	Chr13:50806511-50810020 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020952	protein coding gene	Chr13:46889166-46892675 (+)
PWK/PhJ	MGP_PWKPhJ_G0019546	protein coding gene	Chr13:45596090-45599599 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019374	protein coding gene	Chr13:45597851-45601352 (+)
WSB/EiJ	MGP_WSBEiJ_G0019852	protein coding gene	Chr13:47204705-47208214 (+)

Human Ortholog

BARX1, BARX homeobox 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BARX1, BARX homeobox 1
Links

HGNC:955

NCBI Gene ID: 56033

neXtProt AC: NX_Q9HBU1

UniProt: Q9HBU1
Chr Location

9q22.32; chr9:93951627-93955355 (-) GRCh38

MGI Vertebrate Homology

Barx1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BARX1
Gene Tree

Barx1

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Phenotype Summary

8 phenotypes from 1 allele in 2 genetic backgrounds
1 phenotype from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

1 involving Barx1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation die around E13 embryonic stage with shrunken and malformed stomach or shortly after birth with cleft palate and abnormal tooth development depending on strain background.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1084
Tissues

212
cDNA Data

21
Literature Summary

94

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BARX1

Xenbase barx1

ZFIN barx1

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS49258.1

Ensembl

ENSMUSG00000021381 (Evidence)
NCBI Gene

12022

			Length	Strain/Species	Flank
genomic	12022	NCBI Gene Model \| MGI Sequence Detail	3472	C57BL/6J	± kb
transcript	NM_007526	RefSeq \| MGI Sequence Detail	1366	Not Specified
polypeptide	Q9ER42	UniProt \| EBI \| MGI Sequence Detail	254	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004645 homeobox protein BarH-like 1

(term hierarchy)
InterPro Domains

IPR000047 Helix-turn-helix motif

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR050848 Homeobox domain-containing transcription factors

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

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All nucleic 44

Genomic 2

cDNA 22

Primer pair 9

Other 11

Microarray probesets 3

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MGD-MRK-23988

Summaries

All 122

Developmental Gene Expression 94

Gene Ontology 8

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345835 Qiu C, et al., A single-cell time-lapse of mouse prenatal development from gastrula to birth. Nature. 2024 Feb;626(8001):1084-1093

TSS for Barx1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119663	Chr13:48816001-48816015 (+)	-504 bp
Tssr119664	Chr13:48816361-48816364 (+)	-149 bp
Tssr119665	Chr13:48816383-48816398 (+)	-121 bp
Tssr119666	Chr13:48816435-48816442 (+)	-73 bp
Tssr119667	Chr13:48816465-48816522 (+)	-18 bp
Tssr119668	Chr13:48816538-48816550 (+)	32 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24