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Dnase1 Gene Detail
Summary
  • Symbol
    Dnase1
  • Name
    deoxyribonuclease I
  • Synonyms
    DNaseI, Dnl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103157
    NCBI Gene: 13419
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:3855007-3857888 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.37 cM, cytoband A1-A3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103157
 protein coding gene Chr16:3854806-3857888 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022459
 protein coding gene Chr16:495060-498142 (+)
A/J MGP_AJ_G0022421
 protein coding gene Chr16:364496-367578 (+)
AKR/J MGP_AKRJ_G0022398
 protein coding gene Chr16:505254-508336 (+)
BALB/cJ MGP_BALBcJ_G0022426
 protein coding gene Chr16:490260-493342 (+)
C3H/HeJ MGP_C3HHeJ_G0022193
 protein coding gene Chr16:541009-544091 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022875
 protein coding gene Chr16:537392-540474 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020396
 protein coding gene Chr16:314431-317524 (+)
CAST/EiJ MGP_CASTEiJ_G0021719
 protein coding gene Chr16:504740-507822 (+)
CBA/J MGP_CBAJ_G0022162
 protein coding gene Chr16:610415-613497 (+)
DBA/2J MGP_DBA2J_G0022293
 protein coding gene Chr16:470602-473684 (+)
FVB/NJ MGP_FVBNJ_G0022268
 protein coding gene Chr16:440182-443264 (+)
LP/J MGP_LPJ_G0022361
 protein coding gene Chr16:502613-505695 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022290
 protein coding gene Chr16:491017-494099 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022887
 protein coding gene Chr16:480601-483683 (+)
PWK/PhJ MGP_PWKPhJ_G0021459
 protein coding gene Chr16:511622-514704 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021291
 protein coding gene Chr16:576998-580092 (+)
WSB/EiJ MGP_WSBEiJ_G0021768
 protein coding gene Chr16:505779-508861 (+)



Homology
more
  • Human Ortholog
    DNASE1, deoxyribonuclease 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNASE1, deoxyribonuclease 1
  • Synonyms
    DNL1, DRNI
  • Links
    NCBI Gene ID: 1773
    neXtProt AC: NX_P24855
    UniProt: P24855

  • Chr Location
    16p13.3; chr16:3611728-3680143 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dnase1 mouse models; 1 with human DNASE1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Some heterozygote and homozygote null mice have autoimmune symptoms similar to systemic lupus erythematosus. These include enlarged lymph nodes, circulating auto-antibodies, kidney inflammation and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    97
  • cDNA Data
    213
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13419 NCBI Gene Model | MGI Sequence Detail 2882 C57BL/6J ±  kb
    transcript NM_010061 RefSeq | MGI Sequence Detail 1307 ZRU/MplStud  
    polypeptide P49183 UniProt | EBI | MGI Sequence Detail 284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 215
      cDNA 213
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24023, MGI:2146484
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 6
      Phenotypes 33
    • Earliest
      J:22846 Peitsch MC, et al., Genomic organisation and expression of mouse deoxyribonuclease I. Biochem Biophys Res Commun. 1995 Feb 6;207(1):62-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory