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Azgp1 Gene Detail
Summary
  • Symbol
    Azgp1
  • Name
    alpha-2-glycoprotein 1, zinc
  • Synonyms
    Zag
  • Feature Type
    protein coding gene
  • IDs
    MGI:103163
    NCBI Gene: 12007
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137979783-137988495 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.92 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    384 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103163
 protein coding gene Chr5:137979782-137988495 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030251
 protein coding gene Chr5:142770601-142779318 (+)
A/J MGP_AJ_G0030217
 protein coding gene Chr5:136567107-136576155 (+)
AKR/J MGP_AKRJ_G0030152
 protein coding gene Chr5:141011861-141032825 (+)
BALB/cJ MGP_BALBcJ_G0030229
 protein coding gene Chr5:137956010-137965409 (+)
C3H/HeJ MGP_C3HHeJ_G0029945
 protein coding gene Chr5:141656273-141666968 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030681
 protein coding gene Chr5:148089542-148098255 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027899
 protein coding gene Chr5:130789903-130798432 (+)
CAST/EiJ MGP_CASTEiJ_G0029353
 protein coding gene Chr5:141058976-141069734 (+)
CBA/J MGP_CBAJ_G0029915
 protein coding gene Chr5:153976261-153985365 (+)
DBA/2J MGP_DBA2J_G0030066
 protein coding gene Chr5:136488508-136497816 (+)
FVB/NJ MGP_FVBNJ_G0030021
 protein coding gene Chr5:135653867-135663407 (+)
LP/J MGP_LPJ_G0030155
 protein coding gene Chr5:143288357-143297824 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030053
 protein coding gene Chr5:156778349-156788699 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030722
 protein coding gene Chr5:140860353-140869107 (+)
PWK/PhJ MGP_PWKPhJ_G0029067
 protein coding gene Chr5:135552106-135561939 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028903
 protein coding gene Chr5:138416387-138426886 (+)
WSB/EiJ MGP_WSBEiJ_G0029428
 protein coding gene Chr5:141578701-141588475 (+)



Homology
more
  • Human Ortholog
    AZGP1, alpha-2-glycoprotein 1, zinc-binding
  • Vertebrate Orthologs
    11
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AZGP1, alpha-2-glycoprotein 1, zinc-binding
  • Synonyms
    ZA2G, ZAG
  • Links
    NCBI Gene ID: 563
    neXtProt AC: NX_P25311
    UniProt: P25311

  • Chr Location
    7q22.1; chr7:99966720-99976042 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AZGP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired lipolysis and increased body weight when fed standard food or a high fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    98
  • cDNA Data
    82
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12007 NCBI Gene Model | MGI Sequence Detail 8713 C57BL/6J ±  kb
    transcript NM_013478 RefSeq | MGI Sequence Detail 1315 ZRU/MplStud  
    polypeptide Q64726 UniProt | EBI | MGI Sequence Detail 307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004530 zinc-alpha-2-glycoprotein
      (term hierarchy)
    • InterPro Domains
      IPR050208 Antigen-presenting and immune regulatory MHC class I-related
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR011162 MHC classes I/II-like antigen recognition protein
      IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
      IPR011161 MHC class I-like antigen recognition-like
      IPR037055 MHC class I-like antigen recognition-like superfamily
    • GlyGen
      Q64726 3 sites
    Molecular
    Reagents
    less
    • All nucleic 85
      Genomic 1
      cDNA 82
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24029
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:24018 Ueyama H, et al., Structure and expression of rat and mouse mRNAs for Zn-alpha 2-glycoprotein. J Biochem. 1994 Sep;116(3):677-81
    • Latest
      J:353067 Wen RM, et al., AZGP1 deficiency promotes angiogenesis in prostate cancer. J Transl Med. 2024 Apr 24;22(1):383
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory