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Meox2 Gene Detail
Summary
  • Symbol
    Meox2
  • Name
    mesenchyme homeobox 2
  • Synonyms
    Gax, Mox-2, Mox2
  • Feature Type
    protein coding gene
  • IDs
    MGI:103219
    NCBI Gene: 17286
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:37158539-37229533 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 16.84 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1980 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103219
 protein coding gene Chr12:37158539-37229533 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019695
 protein coding gene Chr12:35379885-35448343 (+)
A/J MGP_AJ_G0019661
 protein coding gene Chr12:34259206-34320161 (+)
AKR/J MGP_AKRJ_G0019632
 protein coding gene Chr12:35301958-35365825 (+)
BALB/cJ MGP_BALBcJ_G0019639
 protein coding gene Chr12:34465844-34526328 (+)
C3H/HeJ MGP_C3HHeJ_G0019443
 protein coding gene Chr12:35254651-35317213 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020086
 protein coding gene Chr12:36371865-36447757 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017710
 protein coding gene Chr12:33351172-33411191 (+)
CAST/EiJ MGP_CASTEiJ_G0018996
 protein coding gene Chr12:30326870-30396147 (+)
CBA/J MGP_CBAJ_G0019415
 protein coding gene Chr12:37573742-37644385 (+)
DBA/2J MGP_DBA2J_G0019528
 protein coding gene Chr12:34111011-34172717 (+)
FVB/NJ MGP_FVBNJ_G0019517
 protein coding gene Chr12:33817556-33879609 (+)
LP/J MGP_LPJ_G0019598
 protein coding gene Chr12:35465906-35537744 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019553
 protein coding gene Chr12:37338736-37444530 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020126
 protein coding gene Chr12:34831427-34903030 (+)
PWK/PhJ MGP_PWKPhJ_G0018763
 protein coding gene Chr12:28798152-28859536 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018553
 protein coding gene Chr12:29497579-29566137 (+)
WSB/EiJ MGP_WSBEiJ_G0019046
 protein coding gene Chr12:35106603-35175417 (+)



Homology
more
  • Human Ortholog
    MEOX2, mesenchyme homeobox 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEOX2, mesenchyme homeobox 2
  • Synonyms
    GAX, MOX2
  • Links
    NCBI Gene ID: 4223
    neXtProt AC: NX_P50222
    UniProt: P50222

  • Chr Location
    7p21.2; chr7:15611212-15686683 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    249 phenotypes from multigenic genotypes
    6 images
    327 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Several mutations that inactivate the gene result in mild defects of rib and vertebrae development. Inactivation in conjunction with a null mutation in a related homeobox gene results in more severe defects stemming from impaired somite formation, patterning, and differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1240
  • Tissues
    243
  • cDNA Data
    34
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17286 NCBI Gene Model | MGI Sequence Detail 70995 C57BL/6J ±  kb
    transcript NM_008584 RefSeq | MGI Sequence Detail 2360 ZRU/MplStud  
    polypeptide P32443 UniProt | EBI | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 2
      cDNA 37
      Primer pair 9
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12395, MGD-MRK-12397, MGD-MRK-24089, MGI:2144856
    References
    more
    • Summaries
      All 402
      Developmental Gene Expression 46
      Diseases 2
      Gene Ontology 11
      Phenotypes 327
    • Earliest
      J:3682 Candia AF, et al., Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development. 1992 Dec;116(4):1123-36
    • Latest
      J:357808 Pelaez MC, et al., Reversal of cognitive deficits in FUS(R521G) amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein induction. Neurotherapeutics. 2024 Sep;21(5):e00388
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory