About   Help   FAQ
Zbtb16 Gene Detail
Summary
  • Symbol
    Zbtb16
  • Name
    zinc finger and BTB domain containing 16
  • Synonyms
    Green's luxoid, PLZF, Zfp145
  • Feature Type
    protein coding gene
  • IDs
    MGI:103222
    NCBI Gene: 235320
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr9:48565597-48747522 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 26.47 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4645 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103222
 protein coding gene Chr9:48563097-48747525 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034764
 protein coding gene Chr9:47427261-47624895 (-)
A/J MGP_AJ_G0034745
 protein coding gene Chr9:46027935-46218701 (-)
AKR/J MGP_AKRJ_G0034673
 protein coding gene Chr9:46986274-47179112 (-)
BALB/cJ MGP_BALBcJ_G0034737
 protein coding gene Chr9:45757644-45940421 (-)
C3H/HeJ MGP_C3HHeJ_G0034447
 protein coding gene Chr9:47442603-47634526 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035257
 protein coding gene Chr9:48800436-48986093 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032170
 protein coding gene Chr9:45530455-45711905 (-)
CAST/EiJ MGP_CASTEiJ_G0033769
 protein coding gene Chr9:47382877-47576120 (-)
CBA/J MGP_CBAJ_G0034419
 protein coding gene Chr9:50510102-50719867 (-)
DBA/2J MGP_DBA2J_G0034578
 protein coding gene Chr9:45883362-46068953 (-)
FVB/NJ MGP_FVBNJ_G0034519
 protein coding gene Chr9:45133736-45323086 (-)
LP/J MGP_LPJ_G0034659
 protein coding gene Chr9:47802439-47998019 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034563
 protein coding gene Chr9:52216451-52418927 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035278
 protein coding gene Chr9:46924761-47120917 (-)
PWK/PhJ MGP_PWKPhJ_G0033474
 protein coding gene Chr9:45851396-46035958 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033309
 protein coding gene Chr9:47234554-47426941 (-)
WSB/EiJ MGP_WSBEiJ_G0033882
 protein coding gene Chr9:46960359-47150008 (-)



Homology
more
  • Human Ortholog
    ZBTB16, zinc finger and BTB domain containing 16
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBTB16, zinc finger and BTB domain containing 16
  • Synonyms
    PLZF, ZNF145
  • Links
    NCBI Gene ID: 7704
    neXtProt AC: NX_Q05516
    UniProt: Q05516

  • Chr Location
    11q23.2; chr11:114059041-114256770 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ZBTB16 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    87 phenotypes from 10 alleles in 14 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit abnormal anterior-posterior patterning, with skeletal abnormalities of the limb, especially the hindlimb, and homeotic transformations of anterior skeletal elements into posterior structures. Males develop infertility due to loss of germline cells with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1358
  • Tissues
    359
  • cDNA Data
    18
  • Literature Summary
    106
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066687 Ensembl Gene Model | MGI Sequence Detail 181926 C57BL/6J ±  kb
    transcript ENSMUST00000093852 Ensembl | MGI Sequence Detail 5114 Not Applicable  
    polypeptide ENSMUSP00000091374 Ensembl | MGI Sequence Detail 673 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 19
      Primer pair 10
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11929, MGD-MRK-24092, MGI:2143075, MGI:96851
    References
    more
    • Summaries
      All 242
      Developmental Gene Expression 106
      Diseases 1
      Gene Ontology 12
      Phenotypes 86
    • Earliest
      J:13069 Green MC, Luxoid, a new hereditary leg and foot abnormality in the house mouse. J Hered. 1955;46(3):91-99
    • Latest
      J:357469 Sivori M, et al., The pelvic organs receive no parasympathetic innervation. Elife. 2024;15
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory