Slk MGI Mouse Gene Detail - MGI:103241

Symbol

Slk
Name

STE20-like kinase
Synonyms

9A2, Etk4, mKIAA0204, mSLK, SLK, Stk2

Feature Type

protein coding gene
IDs

MGI:103241
NCBI Gene: 20874
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr19:47568458-47633685 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 39.77 cM, cytoband D2
Mapping Data

3 experiments

SNPs within 2kb

1162 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103241	protein coding gene	Chr19:47568117-47633685 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025231	protein coding gene	Chr19:47405723-47474683 (+)
A/J	MGP_AJ_G0025207	protein coding gene	Chr19:45028723-45084658 (+)
AKR/J	MGP_AKRJ_G0025176	protein coding gene	Chr19:46502144-46554891 (+)
BALB/cJ	MGP_BALBcJ_G0025202	protein coding gene	Chr19:45083547-45152058 (+)
C3H/HeJ	MGP_C3HHeJ_G0024962	protein coding gene	Chr19:46682006-46745016 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025645	protein coding gene	Chr19:48533463-48595954 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023058	protein coding gene	Chr19:44260614-44318618 (+)
CAST/EiJ	MGP_CASTEiJ_G0024427	protein coding gene	Chr19:46507873-46568885 (+)
CBA/J	MGP_CBAJ_G0024942	protein coding gene	Chr19:51001630-51059668 (+)
DBA/2J	MGP_DBA2J_G0025074	protein coding gene	Chr19:44843876-44910596 (+)
FVB/NJ	MGP_FVBNJ_G0025035	protein coding gene	Chr19:44636168-44697117 (+)
LP/J	MGP_LPJ_G0025160	protein coding gene	Chr19:47295747-47354977 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025066	protein coding gene	Chr19:50247631-50310854 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025703	protein coding gene	Chr19:46621013-46677056 (+)
PWK/PhJ	MGP_PWKPhJ_G0024176	protein coding gene	Chr19:44814858-44872252 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023979	protein coding gene	Chr19:45287500-45343655 (+)
WSB/EiJ	MGP_WSBEiJ_G0024497	protein coding gene	Chr19:46777008-46840623 (+)

Human Ortholog

SLK, STE20 like kinase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLK, STE20 like kinase
Synonyms

bA16H23.1, LOSK, se20-9, STK2
Links

HGNC:11088

NCBI Gene ID: 9748

neXtProt AC: NX_Q9H2G2

UniProt: Q9H2G2
Chr Location

10q24.33-q25.1; chr10:103967140-104029233 (+) GRCh38

MGI Vertebrate Homology

Slk stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLK
Gene Tree

Slk

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Phenotype Summary

28 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

4
Gene trapped

6
Targeted

4
Transgenic

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele die by E14.5, exhibiting severe developmental defects, impaired neuronal and skeletal muscle development, abnormal placental differentiation and vascularization, and increased apoptosis.

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All GO Annotations

56
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

898
Tissues

83
cDNA Data

192
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slk

ZFIN slka

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All Sequences

62
RefSeq

6
UniProt

3
CCDS

CCDS38017.1, CCDS50465.1

Ensembl

ENSMUSG00000025060 (Evidence)
NCBI Gene

20874

			Length	Strain/Species	Flank
genomic	20874	NCBI Gene Model \| MGI Sequence Detail	65228	C57BL/6J	± kb
transcript	NM_009289	RefSeq \| MGI Sequence Detail	7047	C57BL/6
polypeptide	O54988	UniProt \| EBI \| MGI Sequence Detail	1233	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015243 STE20-like serine/threonine-protein kinase

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR022165 Polo kinase kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR051585 STE20 Subfamily Serine/Threonine Kinases

IPR001943 UVR domain
GlyGen

O54988 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)

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All nucleic 195

Genomic 1

cDNA 192

Other 2

Microarray probesets 8

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MGD-MRK-24116, MGI:2147668, MGI:2147725

Summaries

All 65

Developmental Gene Expression 9

Gene Ontology 11

Phenotypes 20
Earliest

J:31015 Hanks SK, et al., The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science. 1988 Jul 1;241(4861):42-52
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156868	Chr19:47567850-47567864 (+)	-601 bp
Tssr156869	Chr19:47568041-47568120 (+)	-377 bp
Tssr156870	Chr19:47568127-47568153 (+)	-318 bp
Tssr156871	Chr19:47568171-47568182 (+)	-281 bp
Tssr156872	Chr19:47573752-47573759 (+)	5,298 bp
Tssr156873	Chr19:47608163-47608176 (+)	39,712 bp
Tssr156874	Chr19:47608190-47608255 (+)	39,765 bp
Tssr156875	Chr19:47608261-47608276 (+)	39,811 bp
Tssr156876	Chr19:47608815-47608830 (+)	40,365 bp
Tssr156877	Chr19:47611067-47611085 (+)	42,618 bp
Tssr156878	Chr19:47611091-47611103 (+)	42,639 bp
Tssr156879	Chr19:47613807-47613828 (+)	45,360 bp
Tssr156880	Chr19:47613867-47613888 (+)	45,420 bp
Tssr156881	Chr19:47624868-47624881 (+)	56,417 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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