Acly MGI Mouse Gene Detail - MGI:103251

Symbol

Acly
Name

ATP citrate lyase
Synonyms

A730098H14Rik

Feature Type

protein coding gene
IDs

MGI:103251
NCBI Gene: 104112
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:100367179-100418826 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 63.47 cM
Mapping Data

2 experiments

SNPs within 2kb

1464 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103251	protein coding gene	Chr11:100367178-100418826 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019158	protein coding gene	Chr11:103237693-103289076 (-)
A/J	MGP_AJ_G0019126	protein coding gene	Chr11:98926708-98978204 (-)
AKR/J	MGP_AKRJ_G0019095	protein coding gene	Chr11:101976004-102032418 (-)
BALB/cJ	MGP_BALBcJ_G0019100	protein coding gene	Chr11:99405610-99457341 (-)
C3H/HeJ	MGP_C3HHeJ_G0018909	protein coding gene	Chr11:102172502-102223816 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019549	protein coding gene	Chr11:106448583-106501656 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017175	protein coding gene	Chr11:96345284-96397268 (-)
CAST/EiJ	MGP_CASTEiJ_G0018463	protein coding gene	Chr11:103151502-103202530 (-)
CBA/J	MGP_CBAJ_G0018878	protein coding gene	Chr11:110876622-110930853 (-)
DBA/2J	MGP_DBA2J_G0018990	protein coding gene	Chr11:98465071-98516394 (-)
FVB/NJ	MGP_FVBNJ_G0018980	protein coding gene	Chr11:97998138-98050605 (-)
LP/J	MGP_LPJ_G0019059	protein coding gene	Chr11:103789800-103843609 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019011	protein coding gene	Chr11:110482216-110535038 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019587	protein coding gene	Chr11:102319880-102371276 (-)
PWK/PhJ	MGP_PWKPhJ_G0018226	protein coding gene	Chr11:99503290-99555165 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018018	protein coding gene	Chr11:102040459-102089605 (-)
WSB/EiJ	MGP_WSBEiJ_G0018512	protein coding gene	Chr11:102302099-102354614 (-)

Human Ortholog

ACLY, ATP citrate lyase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACLY, ATP citrate lyase
Synonyms

ACL, ATPCL, CLATP
Links

HGNC:115

NCBI Gene ID: 47

neXtProt AC: NX_P53396

UniProt: P53396
Chr Location

17q21.2; chr17:41866917-41930545 (-) GRCh38

MGI Vertebrate Homology

Acly stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ACLY
Protein SuperFamily

ATP_citrt_syn
Gene Tree

Acly

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

41
Endonuclease-mediated

5
Gene trapped

28
Targeted

7
Transgenic

1
Genomic Mutations

3 involving Acly
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

66 strains or lines available

Homozygous null mutation of this gene results in embryonic lethality. Heterozygous mutants display no obvious abnormalities. Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.

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All GO Annotations

27
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1147
Tissues

167
cDNA Data

19
Literature Summary

23

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acly

ZFIN aclya

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All Sequences

68
RefSeq

6
UniProt

8
CCDS

CCDS25425.1, CCDS56807.1

Ensembl

ENSMUSG00000020917 (Evidence)
NCBI Gene

104112

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020917	Ensembl Gene Model \| MGI Sequence Detail	51648	C57BL/6J	± kb
transcript	ENSMUST00000107389	Ensembl \| MGI Sequence Detail	4426	Not Applicable
polypeptide	ENSMUSP00000103012	Ensembl \| MGI Sequence Detail	1101	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000003628 ATP-citrate synthase

(term hierarchy)
EC

2.3.3.8
InterPro Domains

IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site

IPR033847 ATP-citrate lyase/succinyl-CoA ligase, conserved site

IPR014608 ATP-citrate synthase

IPR032263 ATP-citrate synthase, citrate-binding domain

IPR005811 ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain

IPR002020 Citrate synthase

IPR016142 Citrate synthase-like, large alpha subdomain

IPR016143 Citrate synthase-like, small alpha subdomain

IPR036969 Citrate synthase superfamily

IPR003781 CoA-binding

IPR036291 NAD(P)-binding domain superfamily

IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site

IPR016102 Succinyl-CoA synthetase-like
GlyGen

Q91V92 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 29

cDNA 20

Primer pair 8

Other 1

Microarray probesets 7

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MGD-MRK-24127, MGI:2144554, MGI:2443004

Summaries

All 103

Developmental Gene Expression 23

Gene Ontology 8

Phenotypes 37
Earliest

J:48625 Elshourbagy NA, et al., Cloning and expression of a human ATP-citrate lyase cDNA. Eur J Biochem. 1992 Mar 1;204(2):491-9
Latest

J:359085 Lazaropoulos MP, et al., Nuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program. Nat Cardiovasc Res. 2024 Jul;3(7):869-882

TSS for Acly:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110828	Chr11:100418722-100418742 (-)	94 bp
Tssr110827	Chr11:100418688-100418704 (-)	130 bp
Tssr110826	Chr11:100407198-100407206 (-)	11,624 bp
Tssr110825	Chr11:100385012-100385030 (-)	33,805 bp
Tssr110824	Chr11:100384988-100385001 (-)	33,831 bp
Tssr110823	Chr11:100367912-100367939 (-)	50,900 bp
Tssr110822	Chr11:100367555-100367558 (-)	51,269 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24