Eif4ebp1 MGI Mouse Gene Detail - MGI:103267 - eukaryotic translation initiation factor 4E binding protein 1

Symbol

Eif4ebp1
Name

eukaryotic translation initiation factor 4E binding protein 1
Synonyms

4e-bp1, PHAS-I

Feature Type

protein coding gene
IDs

MGI:103267
NCBI Gene: 13685
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr8:27750355-27765684 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 15.95 cM, cytoband A4-B1
Mapping Data

4 experiments

SNPs within 2kb

617 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103267	protein coding gene	Chr8:27750355-27766702 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033506	protein coding gene	Chr8:25457571-25475381 (+)
A/J	MGP_AJ_G0033486	protein coding gene	Chr8:24482136-24497916 (+)
AKR/J	MGP_AKRJ_G0033411	protein coding gene	Chr8:25308655-25324024 (+)
BALB/cJ	MGP_BALBcJ_G0033482	protein coding gene	Chr8:24650955-24667054 (+)
C3H/HeJ	MGP_C3HHeJ_G0033196	protein coding gene	Chr8:25512947-25528353 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033998	protein coding gene	Chr8:26431757-26448223 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030948	protein coding gene	Chr8:21735681-21752250 (+)
CAST/EiJ	MGP_CASTEiJ_G0032522	protein coding gene	Chr8:25012346-25027780 (+)
CBA/J	MGP_CBAJ_G0033171	protein coding gene	Chr8:27484797-27503079 (+)
DBA/2J	MGP_DBA2J_G0033326	protein coding gene	Chr8:24452502-24468282 (+)
FVB/NJ	MGP_FVBNJ_G0033270	protein coding gene	Chr8:24261852-24277127 (+)
LP/J	MGP_LPJ_G0033415	protein coding gene	Chr8:25412786-25429792 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033313	protein coding gene	Chr8:26919452-26934947 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034017	protein coding gene	Chr8:25282368-25297721 (+)
PWK/PhJ	MGP_PWKPhJ_G0032233	protein coding gene	Chr8:24114819-24131920 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032067	protein coding gene	Chr8:24656523-24671802 (+)
WSB/EiJ	MGP_WSBEiJ_G0032638	protein coding gene	Chr8:25463638-25480130 (+)

Human Ortholog

EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1
Synonyms

4E-BP1, 4EBP1, BP-1, PHAS-I
Links

HGNC:3288

NCBI Gene ID: 1978

neXtProt AC: NX_Q13541

UniProt: Q13541
Chr Location

8p11.23; chr8:38030534-38060365 (+) GRCh38

MGI Vertebrate Homology

Eif4ebp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EIF4EBP1
Gene Tree

Eif4ebp1

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Phenotype Summary

14 phenotypes from 2 alleles in 3 genetic backgrounds
7 phenotypes from multigenic genotypes
57 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

48
Endonuclease-mediated

3
Gene trapped

39
Targeted

6
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted mutation display hypoglycemia and hypoleptinemia with significantly reduced white fat pads and a notable increase in metabolic rate. Male white adipose tissue exhibits the multilocular appearance of brown adipocytes, and expresses UCP1, a specific marker of brown fat.

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All GO Annotations

36
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

849
Tissues

54
cDNA Data

91
Literature Summary

60

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN eif4ebp1

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS22214.1

Ensembl

ENSMUSG00000031490 (Evidence)
NCBI Gene

13685

			Length	Strain/Species	Flank
genomic	13685	NCBI Gene Model \| MGI Sequence Detail	15330	C57BL/6J	± kb
transcript	NM_007918	RefSeq \| MGI Sequence Detail	981	ZRU/MplStud
polypeptide	Q60876	UniProt \| EBI \| MGI Sequence Detail	117	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006994 eukaryotic translation initiation factor 4E-binding protein 1

(term hierarchy)
InterPro Domains

IPR008606 Eukaryotic translation initiation factor 4E binding
GlyGen

Q60876 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 92

Genomic 1

cDNA 91

Microarray probesets 5

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MGD-MRK-24146, MGI:2142450

Summaries

All 176

Developmental Gene Expression 60

Gene Ontology 11

Phenotypes 57
Earliest

J:27764 Lin TA, et al., Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. J Biol Chem. 1995 Aug 4;270(31):18531-8
Latest

J:359189 So HK, et al., Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss. Research (Wash D C). 2023;6:0158

TSS for Eif4ebp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76776	Chr8:27750349-27750360 (+)	0 bp
Tssr76777	Chr8:27750360-27750398 (+)	24 bp
Tssr76778	Chr8:27750423-27750446 (+)	80 bp
Tssr76779	Chr8:27750457-27750490 (+)	119 bp
Tssr76780	Chr8:27750525-27750537 (+)	176 bp
Tssr76781	Chr8:27751451-27751461 (+)	1,101 bp
Tssr76782	Chr8:27752774-27752788 (+)	2,426 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24