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Zrsr2 Gene Detail
Summary
  • Symbol
    Zrsr2
  • Name
    zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2
  • Synonyms
    35kDa, 5031411E02Rik, A230052C13Rik, U2af1-rs2
  • Feature Type
    protein coding gene
  • IDs
    MGI:103287
    NCBI Gene: 22184
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:162719268-162741662 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 75.99 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    595 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103287
 protein coding gene ChrX:162718439-162741662 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036248
 protein coding gene ChrX:162008794-162031988 (-)
A/J MGP_AJ_G0036218
 protein coding gene ChrX:161181898-161205584 (-)
AKR/J MGP_AKRJ_G0036146
 protein coding gene ChrX:166363252-166386531 (-)
BALB/cJ MGP_BALBcJ_G0036211
 protein coding gene ChrX:159181313-159204487 (-)
C3H/HeJ MGP_C3HHeJ_G0035917
 protein coding gene ChrX:162363134-162386304 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036733
 protein coding gene ChrX:166759155-166782384 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033555
 protein coding gene ChrX:152240599-152264024 (-)
CAST/EiJ MGP_CASTEiJ_G0035206
 protein coding gene ChrX:141334345-141357486 (-)
CBA/J MGP_CBAJ_G0035892
 protein coding gene ChrX:171580300-171603528 (-)
DBA/2J MGP_DBA2J_G0036058
 protein coding gene ChrX:160080533-160103963 (-)
FVB/NJ MGP_FVBNJ_G0035989
 protein coding gene ChrX:159213967-159237241 (-)
LP/J MGP_LPJ_G0036143
 protein coding gene ChrX:163155869-163179055 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036021
 protein coding gene ChrX:180272976-180296470 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036774
 protein coding gene ChrX:161499929-161523144 (-)
PWK/PhJ MGP_PWKPhJ_G0034904
 protein coding gene ChrX:138120795-138143008 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034725
 protein coding gene ChrX:141835000-141858390 (-)
WSB/EiJ MGP_WSBEiJ_G0035341
 protein coding gene ChrX:159463041-159486722 (-)



Homology
more
  • Human Ortholog
    ZRSR2, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZRSR2, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
  • Synonyms
    OFD21, U2AF1L2, U2AF1-RS2, U2AF1RS2, URP, ZC3H22
  • Links
    NCBI Gene ID: 8233
    neXtProt AC: NX_Q15696
    UniProt: Q15696

  • Chr Location
    Xp22.2; chrX:15790156-15830694 (+)  GRCh38
  • Human Ortholog
    ZRSR2P1, ZRSR2 pseudogene 1
  • Synonyms
    U2AF1L1, U2AF1P, U2AF1-RS1, U2AF1RS1, U2AFBPL, ZC3H21, ZRSR1
  • Links
    NCBI Gene ID: 7310
    UniProt: Q15695

  • Chr Location
    5q22.2; chr5:112891610-112893097 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ZRSR2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice inheriting a null allele maternally and a paternal null allele for Zrsr1 fail to develop beyond the 2 cell stage, with very few reaching morula stage and none implanting.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    67
  • cDNA Data
    46
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22184 NCBI Gene Model | MGI Sequence Detail 22395 C57BL/6J ±  kb
    transcript NM_178794 RefSeq | MGI Sequence Detail 3953 C57BL/6  
    polypeptide Q62377 UniProt | EBI | MGI Sequence Detail 462 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000018219 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
      (term hierarchy)
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR003954 RNA recognition motif domain, eukaryote
      IPR009145 U2 auxiliary factor small subunit
      IPR000571 Zinc finger, CCCH-type
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 46
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-24168, MGI:2148049, MGI:2445088, MGI:3036362
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:26190 Yamaoka T, et al., Cloning and mapping of the U2af1-rs2 gene with a high transmission distortion in interspecific backcross progeny. Genomics. 1995 May 20;27(2):337-40
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory