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Apobec1 Gene Detail
Summary
  • Symbol
    Apobec1
  • Name
    apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103298
    NCBI Gene: 11810
  • Alliance
    gene page
  • Transcription Start Sites
    68 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122554751-122579403 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.68 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    780 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103298
 protein coding gene Chr6:122554751-122580068 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031229
 protein coding gene Chr6:125675399-125699714 (-)
A/J MGP_AJ_G0031198
 protein coding gene Chr6:120917429-120942711 (-)
AKR/J MGP_AKRJ_G0031127
 protein coding gene Chr6:124260779-124288351 (-)
BALB/cJ MGP_BALBcJ_G0031207
 protein coding gene Chr6:120605764-120632311 (-)
C3H/HeJ MGP_C3HHeJ_G0030926
 protein coding gene Chr6:124208939-124236354 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031666
 protein coding gene Chr6:128972272-129001738 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028825
 protein coding gene Chr6:117526350-117556303 (-)
CAST/EiJ MGP_CASTEiJ_G0030316
 protein coding gene Chr6:124477085-124502223 (-)
CBA/J MGP_CBAJ_G0030890
 protein coding gene Chr6:134005152-134033501 (-)
DBA/2J MGP_DBA2J_G0031046
 protein coding gene Chr6:119833099-119861542 (-)
FVB/NJ MGP_FVBNJ_G0030998
 protein coding gene Chr6:118782597-118807343 (-)
LP/J MGP_LPJ_G0031126
 protein coding gene Chr6:125826378-125851240 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031033
 protein coding gene Chr6:137965915-138004366 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031696
 protein coding gene Chr6:124159293-124183842 (-)
PWK/PhJ MGP_PWKPhJ_G0030030
 protein coding gene Chr6:118666557-118705020 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029857
 protein coding gene Chr6:122281618-122311802 (-)
WSB/EiJ MGP_WSBEiJ_G0030398
 protein coding gene Chr6:124459634-124489371 (-)



Homology
more
  • Human Ortholog
    APOBEC1, apolipoprotein B mRNA editing enzyme catalytic subunit 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOBEC1, apolipoprotein B mRNA editing enzyme catalytic subunit 1
  • Synonyms
    APO1, APOBEC-1, BEDP, CDAR1, HEPR
  • Links
    NCBI Gene ID: 339
    neXtProt AC: NX_P41238
    UniProt: P41238

  • Chr Location
    12p13.31; chr12:7649400-7670599 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 5 alleles in 6 genetic backgrounds
    17 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal lipid homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    104
  • cDNA Data
    57
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040613 Ensembl Gene Model | MGI Sequence Detail 24653 C57BL/6J ±  kb
    transcript ENSMUST00000112585 Ensembl | MGI Sequence Detail 2127 Not Applicable  
    polypeptide ENSMUSP00000108204 Ensembl | MGI Sequence Detail 229 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 4
      cDNA 58
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24181
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 20
      Phenotypes 59
    • Earliest
      J:25752 Nakamuta M, et al., Alternative mRNA splicing and differential promoter utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice. Structure and evolution of Apobec1 and related nucleoside/nucleotide deaminases. J Biol Chem. 1995 Jun 2;270(22):13042-56
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory