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Xk Gene Detail
Summary
  • Symbol
    Xk
  • Name
    X-linked Kx blood group
  • Synonyms
    1810038K19Rik, Xk
  • Feature Type
    protein coding gene
  • IDs
    MGI:103569
    NCBI Gene: 22439
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:9139023-9179484 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 4.22 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    926 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103569
 protein coding gene ChrX:9138995-9179489 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035555
 protein coding gene ChrX:3993463-4042158 (+)
A/J MGP_AJ_G0035532
 protein coding gene ChrX:4054551-4116952 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0035525
 protein coding gene ChrX:4009840-4061906 (+)
C3H/HeJ MGP_C3HHeJ_G0035242
 protein coding gene ChrX:4168598-4182146 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036055
 protein coding gene ChrX:4041187-4095017 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032924
 protein coding gene ChrX:3427772-3467299 (+)
CAST/EiJ MGP_CASTEiJ_G0034534
 protein coding gene ChrX:3877708-3923857 (+)
CBA/J MGP_CBAJ_G0035211
 protein coding gene ChrX:4436841-4454547 (+)
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0035354
 protein coding gene ChrX:4276136-4325534 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036067
 protein coding gene ChrX:3937277-3980792 (+)
PWK/PhJ MGP_PWKPhJ_G0034236
 protein coding gene ChrX:3801805-3864679 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034075
 protein coding gene ChrX:4038720-4111935 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    XK, X-linked Kx blood group antigen, Kell and VPS13A binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XK, X-linked Kx blood group antigen, Kell and VPS13A binding protein
  • Synonyms
    KX, NA, NAC, X1k, XKR1
  • Links
    NCBI Gene ID: 7504
    neXtProt AC: NX_P51811
    UniProt: P51811

  • Chr Location
    Xp21.1; chrX:37685791-37732130 (+)  GRCh38
  • MGI Vertebrate Homology
    Xk stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: XK
  • Gene Tree
    Xk
Human Diseases
more
  • Diseases
    2 with human XK associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Aging homozygous null females exhibit abnormal skeletal muscle fiber morphology and giant axon changes with variable paranodal demyelination in the spinal cord and sciatic nerve. Hemizygous males show increased corpuscular hemoglobin concentration and increased erythrocyte Ca2+ and Mg2+ ion levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    28
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22439 NCBI Gene Model | MGI Sequence Detail 40462 C57BL/6J ±  kb
    transcript NM_023500 RefSeq | MGI Sequence Detail 5062 ZRU/MplStud  
    polypeptide Q9QXY7 UniProt | EBI | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 14
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24454, MGI:1916432
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:26635 Blair HJ, et al., High-resolution comparative mapping of the proximal region of the mouse X chromosome. Genomics. 1995 Jul 20;28(2):305-10
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory