In(4)56Rk Cytogenetic Marker Detail

Summary

• Symbol
  In(4)56Rk
• Name
  inversion, Chr 4, Roderick 56
• Synonyms
  Gnb1^Rd4, In56Rk

• Feature Type
  chromosomal inversion
• IDs
  MGI:103782
  NCBI Gene: 16287

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 4, Syntenic
• Mapping Data
  6 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  9 phenotypes from 1 allele in 1 genetic background
  7 phenotype references
  

• All Mutations and Alleles
  1
• Radiation induced
  1
• Find Mice (IMSR)
  1 strains or lines available

Mice homozygous for a spontaneous mutation found in a stock carrying the large Chr 4 inversion In(4)56Rk exhibit prenatal lethality; heterozygotes display abnormal eye electrophysiology, attenuated retinal vessels, pigment spots, ocular fundus atrophy, and retinal degeneration.

Sequences &
Gene Models

• NCBI Gene
  16287

Other
Accession IDs

MGD-MRK-13814, MGD-MRK-25103, MGI:97885

References

• Summaries
  All 10

  Phenotypes 7
• Earliest
  J:41514 Roderick TH, et al., A new dominant retinal degeneration (Rd4) associated with a chromosomal inversion in the mouse. Genomics. 1997 Jun 15;42(3):393-6
• Latest
  J:220643 Tochitsky I, et al., Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells. Neuron. 2014 Feb 19;81(4):800-13