T(7;18)50H Cytogenetic Marker Detail

Summary

• Symbol
  T(7;18)50H
• Name
  reciprocal translocation, Chr 7 and 18, Harwell 50
• Synonyms
  T50H

• Feature Type
  reciprocal chromosomal translocation
• IDs
  MGI:103976
  NCBI Gene: 21267

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 18, cytoband B2
• Mapping Data
  4 experiments

Human Diseases

• Diseases
  1 with T(7;18)50H mouse models

Human Disease

Mouse Models

Prader-Willi syndrome

IDs

Prader-Willi syndrome      

DOID:11983
ICD10CM:Q87.11
ICD9CM:759.81
MESH:D011218
NCI:C75463
OMIM:176270
ORDO:739
UMLS_CUI:C0032897

View 1 model

Mouse Models

Human Disease Modeled: Prader-Willi syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
T(7;18)50H/+	involves: 101/H * C3H/HeH	J:3618	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  25 phenotypes from 1 allele in 3 genetic backgrounds
  3 images
  9 phenotype references
  

• All Mutations and Alleles
  1
• Radiation induced
  1
• Find Mice (IMSR)
  2 strains or lines available

Mice heterozygous for this reciprocal translocation have reduced fertility. Unbalanced forms of this translocation comprising maternal or paternal duplication of Chr7 segments are used to study associated imprinted phenotypes.

Sequences &
Gene Models

• NCBI Gene
  21267

Other
Accession IDs

MGD-MRK-25298

References

• Summaries
  All 13

  Diseases 1

  Phenotypes 9
• Earliest
  J:12947 Lyon MF, et al., The overall rates of dominant and recessive lethal and visible mutation induced by spermatogonial X-irradiation of mice. Genet Res. 1964;5(3):448-467
• Latest
  J:198496 Resnick JL, et al., Recommendations for the investigation of animal models of Prader-Willi syndrome. Mamm Genome. 2013 Jun;24(5-6):165-78