Tyro3 MGI Mouse Gene Detail - MGI:104294 - TYRO3 protein tyrosine kinase 3

Symbol

Tyro3
Name

TYRO3 protein tyrosine kinase 3
Synonyms

Brt, Dtk, Etk-2, Rse, Sky, Sky, Tif

Feature Type

protein coding gene
IDs

MGI:104294
NCBI Gene: 22174
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:119628214-119648585 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 59.97 cM, cytoband F
Mapping Data

12 experiments

SNPs within 2kb

417 from dbSNP Build 142
Strain Annotations

18
RFLP

7

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104294	protein coding gene	Chr2:119628123-119648585 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026353	protein coding gene	Chr2:122632501-122652838 (+)
A/J	MGP_AJ_G0026314	protein coding gene	Chr2:117606895-117627255 (+)
AKR/J	MGP_AKRJ_G0026293	protein coding gene	Chr2:120889840-120910224 (+)
BALB/cJ	MGP_BALBcJ_G0026327	protein coding gene	Chr2:117848724-117869597 (+)
C3H/HeJ	MGP_C3HHeJ_G0026073	protein coding gene	Chr2:121354714-121375137 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026774	protein coding gene	Chr2:126622780-126643149 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024154	protein coding gene	Chr2:112634361-112655424 (+)
CAST/EiJ	MGP_CASTEiJ_G0025535	protein coding gene	Chr2:121673336-121696661 (+)
CBA/J	MGP_CBAJ_G0026049	protein coding gene	Chr2:131061285-131084892 (+)
DBA/2J	MGP_DBA2J_G0026188	protein coding gene	Chr2:117002233-117022593 (+)
FVB/NJ	MGP_FVBNJ_G0026150	protein coding gene	Chr2:115833307-115853958 (+)
LP/J	MGP_LPJ_G0026289	protein coding gene	Chr2:122894267-122914531 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026169	protein coding gene	Chr2:135385780-135406164 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026829	protein coding gene	Chr2:121011302-121032812 (+)
PWK/PhJ	MGP_PWKPhJ_G0025271	protein coding gene	Chr2:116589232-116609645 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025070	protein coding gene	Chr2:120197825-120219066 (+)
WSB/EiJ	MGP_WSBEiJ_G0025604	protein coding gene	Chr2:121842978-121864917 (+)

Human Ortholog

TYRO3, TYRO3 protein tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TYRO3, TYRO3 protein tyrosine kinase
Synonyms

BYK, Dtk, Etk-2, Rek, RSE, Sky, Tif
Links

HGNC:12446

NCBI Gene ID: 7301

neXtProt AC: NX_Q06418

UniProt: Q06418
Chr Location

15q15.1; chr15:41557675-41583589 (+) GRCh38

MGI Vertebrate Homology

Tyro3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TYRO3
Protein SuperFamily

TyrPK_CSF1-R
Gene Tree

Tyro3

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

19 phenotypes from 2 alleles in 2 genetic backgrounds
62 phenotypes from multigenic genotypes
61 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

49
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

37
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

2 involving Tyro3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity, and aberrant apoptosis.

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All GO Annotations

96
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

815
Tissues

50
cDNA Data

115
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AXL

Xenbase tyro3

ZFIN tyro3

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All Sequences

62
RefSeq

8
UniProt

2
CCDS

CCDS16611.1, CCDS71119.1

Ensembl

ENSMUSG00000027298 (Evidence)
NCBI Gene

22174

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027298	Ensembl Gene Model \| MGI Sequence Detail	20372	C57BL/6J	± kb
transcript	ENSMUST00000028763	Ensembl \| MGI Sequence Detail	3989	Not Applicable
polypeptide	ENSMUSP00000028763	Ensembl \| MGI Sequence Detail	880	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016878 tyrosine-protein kinase receptor TYRO3

(term hierarchy)
PDB

3QUP, 4FEQ, 4FF8
EC

2.7.10.1
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050122 Receptor Tyrosine Kinase

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain
GlyGen

P55144 8 sites, 4 N-linked glycans (5 sites)

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All nucleic 141

Genomic 18

cDNA 115

Primer pair 6

Other 2

Microarray probesets 5

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MGD-MRK-1334, MGD-MRK-25620, MGD-MRK-37049, MGI:2138899

Summaries

All 149

Developmental Gene Expression 19

Diseases 1

Gene Ontology 22

Phenotypes 61
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345894 Miao S, et al., Tyro3 promotes the maturation of glutamatergic synapses. Front Neurosci. 2024;18:1327423

TSS for Tyro3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19659	Chr2:119628959-119628970 (+)	751 bp
Tssr19660	Chr2:119630023-119630053 (+)	1,824 bp
Tssr19661	Chr2:119630055-119630073 (+)	1,850 bp
Tssr19662	Chr2:119630206-119630241 (+)	2,010 bp
Tssr19663	Chr2:119630245-119630266 (+)	2,042 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24