Tnfrsf4 MGI Mouse Gene Detail - MGI:104512 - tumor necrosis factor receptor superfamily, member 4

Symbol

Tnfrsf4
Name

tumor necrosis factor receptor superfamily, member 4
Synonyms

ACT35, CD134, Ox40, Txgp1

Feature Type

protein coding gene
IDs

MGI:104512
NCBI Gene: 22163
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr4:156098300-156101069 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 87.68 cM
Mapping Data

3 experiments

SNPs within 2kb

211 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104512	protein coding gene	Chr4:156098049-156101070 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029243	protein coding gene	Chr4:160383619-160386400 (+)
A/J	MGP_AJ_G0029208	protein coding gene	Chr4:153623700-153626481 (+)
AKR/J	MGP_AKRJ_G0029156	protein coding gene	Chr4:157804471-157807252 (+)
BALB/cJ	MGP_BALBcJ_G0029224	protein coding gene	Chr4:154099507-154102288 (+)
C3H/HeJ	MGP_C3HHeJ_G0028945	protein coding gene	Chr4:158367563-158370344 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029673	protein coding gene	Chr4:166065059-166067828 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026917	protein coding gene	Chr4:145901308-145904126 (+)
CAST/EiJ	MGP_CASTEiJ_G0028357	protein coding gene	Chr4:155805470-155808296 (+)
CBA/J	MGP_CBAJ_G0028907	protein coding gene	Chr4:171107601-171110382 (+)
DBA/2J	MGP_DBA2J_G0029056	protein coding gene	Chr4:153645030-153647811 (+)
FVB/NJ	MGP_FVBNJ_G0029019	protein coding gene	Chr4:152893007-152895776 (+)
LP/J	MGP_LPJ_G0029146	protein coding gene	Chr4:160319972-160322735 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029046	protein coding gene	Chr4:173899272-173902041 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029705	protein coding gene	Chr4:158449337-158452118 (+)
PWK/PhJ	MGP_PWKPhJ_G0028078	protein coding gene	Chr4:149784341-149787109 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027912	protein coding gene	Chr4:152696660-152699428 (+)
WSB/EiJ	MGP_WSBEiJ_G0028437	protein coding gene	Chr4:158613540-158616321 (+)

Human Ortholog

TNFRSF4, TNF receptor superfamily member 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNFRSF4, TNF receptor superfamily member 4
Synonyms

ACT35, CD134, IMD16, OX40, TXGP1L
Links

HGNC:11918

NCBI Gene ID: 7293

neXtProt AC: NX_P43489

UniProt: P43489
Chr Location

1p36.33; chr1:1211326-1214153 (-) GRCh38

MGI Vertebrate Homology

Tnfrsf4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TNFRSF4
Gene Tree

Tnfrsf4

Diseases

1 with human TNFRSF4 associations

				Human Disease	Mouse Models
				immunodeficiency 16 IDs immunodeficiency 16 DOID:0111935 OMIM:615593 ORDO:431149 UMLS_CUI:C3810053

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
52 phenotypes from multigenic genotypes
1 images
93 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

11
Targeted

6
Find Mice (IMSR)

36 strains or lines available

Homozygote null mice have defects in T cell response to antigen including proliferation, production of cytokines, and generation of memory T cells.

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All GO Annotations

24
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

35
RefSeq

4
UniProt

2
CCDS

CCDS19055.1

Ensembl

ENSMUSG00000029075 (Evidence)
NCBI Gene

22163

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029075	Ensembl Gene Model \| MGI Sequence Detail	2770	C57BL/6J	± kb
transcript	ENSMUST00000030952	Ensembl \| MGI Sequence Detail	1030	Not Applicable
polypeptide	ENSMUSP00000030952	Ensembl \| MGI Sequence Detail	272	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001960 tumor necrosis factor receptor superfamily member 4

(term hierarchy)
InterPro Domains

IPR001368 TNFR/NGFR cysteine-rich region

IPR020445 Tumour necrosis factor receptor 4

IPR034022 Tumour necrosis factor receptor 4, N-terminal
GlyGen

P47741 2 sites, 1 N-linked glycan (1 site)

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All nucleic 8

Genomic 1

cDNA 7

Microarray probesets 3

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MGD-MRK-13094, MGD-MRK-25943

Summaries

All 173

Developmental Gene Expression 1

Gene Ontology 13

Phenotypes 93
Earliest

J:15504 Calderhead DM, et al., Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. J Immunol. 1993 Nov 15;151(10):5261-71
Latest

J:347288 Yu J, et al., The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8(+) T-cell immunity. Cell Mol Immunol. 2023 Dec;20(12):1445-1456

TSS for Tnfrsf4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40766	Chr4:156097014-156097023 (+)	-1,281 bp
Tssr40767	Chr4:156097038-156097043 (+)	-1,259 bp
Tssr40768	Chr4:156097057-156097062 (+)	-1,240 bp
Tssr40769	Chr4:156097265-156097276 (+)	-1,029 bp
Tssr40770	Chr4:156097430-156097478 (+)	-846 bp
Tssr40771	Chr4:156098292-156098306 (+)	-1 bp
Tssr40772	Chr4:156098315-156098329 (+)	22 bp
Tssr40773	Chr4:156098355-156098366 (+)	61 bp
Tssr40774	Chr4:156098764-156098775 (+)	470 bp
Tssr40775	Chr4:156099152-156099165 (+)	859 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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