Nqo2 MGI Mouse Gene Detail - MGI:104513 - N-ribosyldihydronicotinamide quinone reductase 2

Symbol

Nqo2
Name

N-ribosyldihydronicotinamide quinone reductase 2
Synonyms

Nmor2, NRH: quinone oxidoreductase, Ox-2, Ox2

Feature Type

protein coding gene
IDs

MGI:104513
NCBI Gene: 18105
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr13:34148670-34172426 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 14.01 cM, cytoband A4
Mapping Data

3 experiments

SNPs within 2kb

738 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104513	protein coding gene	Chr13:34148642-34172448 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020444	protein coding gene	Chr13:32066553-32091300 (+)
A/J	MGP_AJ_G0020399	protein coding gene	Chr13:31125312-31149413 (+)
AKR/J	MGP_AKRJ_G0020376	protein coding gene	Chr13:31860259-31886260 (+)
BALB/cJ	MGP_BALBcJ_G0020394	protein coding gene	Chr13:31202071-31225995 (+)
C3H/HeJ	MGP_C3HHeJ_G0020193	protein coding gene	Chr13:31792016-31815414 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020828	protein coding gene	Chr13:33132277-33160145 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018415	protein coding gene	Chr13:29440539-29463575 (+)
CAST/EiJ	MGP_CASTEiJ_G0019709	protein coding gene	Chr13:31449861-31473920 (+)
CBA/J	MGP_CBAJ_G0020153	protein coding gene	Chr13:34577525-34604108 (+)
DBA/2J	MGP_DBA2J_G0020275	protein coding gene	Chr13:30650379-30681029 (+)
FVB/NJ	MGP_FVBNJ_G0020255	protein coding gene	Chr13:30230389-30257201 (+)
LP/J	MGP_LPJ_G0020351	protein coding gene	Chr13:32294036-32319535 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020286	protein coding gene	Chr13:34796481-34824891 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020871	protein coding gene	Chr13:31518513-31547160 (+)
PWK/PhJ	MGP_PWKPhJ_G0019464	protein coding gene	Chr13:30766656-30795998 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019289	protein coding gene	Chr13:30170921-30193095 (+)
WSB/EiJ	MGP_WSBEiJ_G0019771	protein coding gene	Chr13:31877699-31903890 (+)

Human Ortholog

NQO2, N-ribosyldihydronicotinamide:quinone dehydrogenase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NQO2, N-ribosyldihydronicotinamide:quinone dehydrogenase 2
Synonyms

DHQV, DIA6, NMOR2, QR2
Links

HGNC:7856

NCBI Gene ID: 4835

neXtProt AC: NX_P16083

UniProt: P16083
Chr Location

6p25.2; chr6:2987987-3019755 (+) GRCh38

MGI Vertebrate Homology

Nqo2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NQO2
Gene Tree

Nqo2

Diseases

4 with human NQO2 associations

				Human Disease	Mouse Models
				agranulocytosis IDs agranulocytosis DOID:12987 ICD10CM:D70 MESH:D000380 UMLS_CUI:C0001824
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				breast carcinoma IDs breast carcinoma DOID:3459 EFO:0000305 MESH:D001943 NCI:C4872 UMLS_CUI:C0678222
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

9
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Nqo2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available

Mice homozygouse for disruptions in this gene have an essentially normal phenotype but with abnormalities in WBC counts and increased susceptibility to chemically induced tumors.

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All GO Annotations

32
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

1
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

83
RefSeq

38
UniProt

5
CCDS

CCDS26442.1, CCDS88437.1

Ensembl

ENSMUSG00000046949 (Evidence)
NCBI Gene

18105

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046949	Ensembl Gene Model \| MGI Sequence Detail	23757	C57BL/6J	± kb
transcript	ENSMUST00000058978	Ensembl \| MGI Sequence Detail	3842	Not Applicable
polypeptide	ENSMUSP00000053809	Ensembl \| MGI Sequence Detail	231	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011389 ribosyldihydronicotinamide dehydrogenase [quinone]

(term hierarchy)
EC

1.10.5.1
InterPro Domains

IPR003680 Flavodoxin-like fold

IPR029039 Flavoprotein-like superfamily

IPR051545 NAD(P)H dehydrogenase (quinone)
GlyGen

Q9JI75 1 site, 1 O-linked glycan (1 site)

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 5

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MGD-MRK-13091, MGD-MRK-13093, MGD-MRK-25944

Summaries

All 55

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 23
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:343492 Janda E, et al., Autophagy and neuroprotection in astrocytes exposed to 6-hydroxydopamine is negatively regulated by NQO2: relevance to Parkinson's disease. Sci Rep. 2023 Dec 7;13(1):21624

TSS for Nqo2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119199	Chr13:34148646-34148657 (+)	-18 bp
Tssr119200	Chr13:34148667-34148687 (+)	7 bp
Tssr119201	Chr13:34148691-34148733 (+)	42 bp
Tssr119202	Chr13:34148747-34148754 (+)	81 bp
Tssr119203	Chr13:34148918-34148950 (+)	264 bp
Tssr119204	Chr13:34151084-34151091 (+)	2,418 bp
Tssr119205	Chr13:34163673-34163677 (+)	15,005 bp
Tssr4038	Chr13:34169321-34169340 (+)	20,661 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24