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Bmp8a Gene Detail
Summary
  • Symbol
    Bmp8a
  • Name
    bone morphogenetic protein 8a
  • Synonyms
    Bmp7r1, OP2, osteogenic protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104515
    NCBI Gene: 12163
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:123206438-123237045 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 57.42 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    824 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104515
 protein coding gene Chr4:123206438-123237045 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028740
 protein coding gene Chr4:124757712-124789704 (-)
A/J MGP_AJ_G0028699
 protein coding gene Chr4:119889300-119924751 (-)
AKR/J MGP_AKRJ_G0028652
 protein coding gene Chr4:123117281-123153938 (-)
BALB/cJ MGP_BALBcJ_G0028721
 protein coding gene Chr4:120458026-120490600 (-)
C3H/HeJ MGP_C3HHeJ_G0028437
 protein coding gene Chr4:123229745-123277657 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029163
 protein coding gene Chr4:129564586-129600659 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026436
 protein coding gene Chr4:113093239-113123645 (-)
CAST/EiJ MGP_CASTEiJ_G0027868
 protein coding gene Chr4:121246897-121294850 (-)
CBA/J MGP_CBAJ_G0028402
 protein coding gene Chr4:132850525-132898032 (-)
DBA/2J MGP_DBA2J_G0028551
 protein coding gene Chr4:120379564-120412759 (-)
FVB/NJ MGP_FVBNJ_G0028518
 protein coding gene Chr4:119000757-119038543 (-)
LP/J MGP_LPJ_G0028652
 protein coding gene Chr4:125028963-125066707 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028544
 protein coding gene Chr4:137798414-137829459 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029201
 protein coding gene Chr4:123500324-123535291 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0027416
 protein coding gene Chr4:119310529-119349504 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    BMP8A, bone morphogenetic protein 8a
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMP8A, bone morphogenetic protein 8a
  • Synonyms
    Op2, OP-2
  • Links
    NCBI Gene ID: 353500
    neXtProt AC: NX_Q7Z5Y6
    UniProt: Q7Z5Y6

  • Chr Location
    1p34.3; chr1:39491636-39529869 (+)  GRCh38
  • Human Ortholog
    BMP8B, bone morphogenetic protein 8b
  • Synonyms
    BMP8, OP2
  • Links
    NCBI Gene ID: 656
    neXtProt AC: NX_P34820
    UniProt: P34820

  • Chr Location
    1p34.2; chr1:39757182-39788865 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
About half of the males homozygous for targeted mutations of this gene show spermatogenesis defects and germ cell degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    69
  • cDNA Data
    11
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12163 NCBI Gene Model | MGI Sequence Detail 30608 C57BL/6J ±  kb
    transcript NM_001256019 RefSeq | MGI Sequence Detail 2405 Not Specified  
    polypeptide P34821 UniProt | EBI | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR029034 Cystine-knot cytokine
      IPR001111 TGF-beta, propeptide
      IPR017948 Transforming growth factor beta, conserved site
      IPR001839 Transforming growth factor-beta, C-terminal
      IPR015615 Transforming growth factor-beta-related
    • GlyGen
      P34821 2 sites
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 2
      cDNA 11
      Primer pair 7
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18614, MGD-MRK-25946
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 18
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:19593 Ozkaynak E, et al., Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. J Biol Chem. 1992 Dec 15;267(35):25220-7
    • Latest
      J:335592 de Lope C, et al., Dysfunction of programmed embryo senescence is linked to genetic developmental defects. Development. 2023 May 1;150(9):dev200903
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory