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Tns1 Gene Detail
Summary
  • Symbol
    Tns1
  • Name
    tensin 1
  • Synonyms
    1110018I21Rik, 1200014E20Rik, E030018G17Rik, E030037J05Rik, Tns
  • Feature Type
    protein coding gene
  • IDs
    MGI:104552
    NCBI Gene: 21961
  • Alliance
    gene page
  • Transcription Start Sites
    71 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:73949390-74163608 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.17 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5837 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104552
 protein coding gene Chr1:73949390-74163707 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016139
 protein coding gene Chr1:74483268-74706429 (-)
A/J MGP_AJ_G0016122
 protein coding gene Chr1:71871535-72090731 (-)
AKR/J MGP_AKRJ_G0016079
 protein coding gene Chr1:73868627-74095932 (-)
BALB/cJ MGP_BALBcJ_G0016077
 protein coding gene Chr1:71943216-72159706 (-)
C3H/HeJ MGP_C3HHeJ_G0015908
 protein coding gene Chr1:74205208-74420120 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016530
 protein coding gene Chr1:77387823-77609734 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014251
 protein coding gene Chr1:67457080-67670724 (-)
CAST/EiJ MGP_CASTEiJ_G0015492
 protein coding gene Chr1:73509309-73729284 (-)
CBA/J MGP_CBAJ_G0015881
 protein coding gene Chr1:79889818-80118887 (-)
DBA/2J MGP_DBA2J_G0015982
 protein coding gene Chr1:71207120-71421991 (-)
FVB/NJ MGP_FVBNJ_G0015985
 protein coding gene Chr1:70379417-70599332 (-)
LP/J MGP_LPJ_G0016054
 protein coding gene Chr1:75578811-75799862 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016005
 protein coding gene Chr1:83324792-83556101 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016577
 protein coding gene Chr1:73927574-74144308 (-)
PWK/PhJ MGP_PWKPhJ_G0015279
 protein coding gene Chr1:70620053-70864512 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015057
 protein coding gene Chr1:73273654-73511563 (-)
WSB/EiJ MGP_WSBEiJ_G0015554
 protein coding gene Chr1:73721921-73949992 (-)



Homology
more
  • Human Ortholog
    TNS1, tensin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNS1, tensin 1
  • Synonyms
    MST091, MST122, MST127, MSTP091, MSTP122, MSTP127, MXRA6, PPP1R155, TNS
  • Links
    NCBI Gene ID: 7145
    neXtProt AC: NX_Q9HBL0
    UniProt: Q9HBL0

  • Chr Location
    2q35; chr2:217799588-218033982 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 1 allele in 2 genetic backgrounds
    2 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced female fertility, and develop kidney cysts and progressive kidney degeneration that may lead to death from renal failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    29
  • cDNA Data
    190
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055322 Ensembl Gene Model | MGI Sequence Detail 214219 C57BL/6J ±  kb
    transcript ENSMUST00000169786 Ensembl | MGI Sequence Detail 9966 Not Applicable  
    polypeptide ENSMUSP00000127715 Ensembl | MGI Sequence Detail 1888 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 194
      Genomic 1
      cDNA 191
      Primer pair 1
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-25984, MGI:1915754, MGI:1918975, MGI:2138313, MGI:2444104
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:231945 Dina C, et al., Genetic association analyses highlight biological pathways underlying mitral valve prolapse. Nat Genet. 2015 Oct;47(10):1206-11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory