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Clcn4 Gene Detail
Summary
  • Symbol
    Clcn4
  • Name
    chloride channel, voltage-sensitive 4
  • Synonyms
    Clc4-2, Clcn4-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104571
    NCBI Gene: 12727
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:7285308-7303837 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 4.23 cM, cytoband A2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    638 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104571
 protein coding gene Chr7:7285308-7303850 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031619
 protein coding gene Chr7:4406780-4423936 (-)
A/J MGP_AJ_G0031594
 protein coding gene Chr7:4260772-4279994 (-)
AKR/J MGP_AKRJ_G0031520
 protein coding gene Chr7:4587612-4616791 (-)
BALB/cJ MGP_BALBcJ_G0031602
 protein coding gene Chr7:4362819-4381779 (-)
C3H/HeJ MGP_C3HHeJ_G0031322
 protein coding gene Chr7:4404500-4425986 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032065
 protein coding gene Chr7:4643855-4666788 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029176
 protein coding gene Chr7:3924758-3980331 (-)
CAST/EiJ MGP_CASTEiJ_G0030684
 protein coding gene Chr7:4226975-4245290 (-)
CBA/J MGP_CBAJ_G0031279
 protein coding gene Chr7:4786126-4815544 (-)
DBA/2J MGP_DBA2J_G0031437
 protein coding gene Chr7:4344351-4361067 (-)
FVB/NJ MGP_FVBNJ_G0031391
 protein coding gene Chr7:4278670-4296518 (-)
LP/J MGP_LPJ_G0031523
 protein coding gene Chr7:4512830-4530045 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031430
 protein coding gene Chr7:4780147-4800772 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032093
 protein coding gene Chr7:4312412-4329694 (-)
PWK/PhJ MGP_PWKPhJ_G0030411
 protein coding gene Chr7:4449292-4467733 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030238
 protein coding gene Chr7:3777455-3837246 (-)
WSB/EiJ MGP_WSBEiJ_G0030778
 protein coding gene Chr7:4470123-4488289 (-)



Homology
more
  • Human Ortholog
    CLCN4, chloride voltage-gated channel 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLCN4, chloride voltage-gated channel 4
  • Synonyms
    ClC-4, CLC4, ClC-4A, MRX15, MRX49, MRXSRC
  • Links
    NCBI Gene ID: 1183
    neXtProt AC: NX_P51793
    UniProt: P51793

  • Chr Location
    Xp22.2; chrX:10156975-10237660 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CLCN4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    5 phenotype references
Mice homozygous for a knock-out allele exhibit no obvious phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    13
  • cDNA Data
    13
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12727 NCBI Gene Model | MGI Sequence Detail 18530 C57BL/6J ±  kb
transcript NR_178086 RefSeq | MGI Sequence Detail 5263 ZRU/MplStud  
polypeptide Q61418 UniProt | EBI | MGI Sequence Detail 747 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 22
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-26005
References
more
  • Summaries
    All 42
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 5
  • Earliest
    J:26310 Rugarli EI, et al., Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice [see comments]. Nat Genet. 1995 Aug;10(4):466-71
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory