Il12rb1 MGI Mouse Gene Detail - MGI:104579 - interleukin 12 receptor, beta 1

Symbol

Il12rb1
Name

interleukin 12 receptor, beta 1
Synonyms

CD212, IL-12R[b]

Feature Type

protein coding gene
IDs

MGI:104579
NCBI Gene: 16161
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:71261093-71274068 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.21 cM
Mapping Data

6 experiments

SNPs within 2kb

323 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104579	protein coding gene	Chr8:71261005-71276186 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033728	protein coding gene	Chr8:71111569-71124545 (+)
A/J	MGP_AJ_G0033711	protein coding gene	Chr8:68213727-68226696 (+)
AKR/J	MGP_AKRJ_G0033636	protein coding gene	Chr8:70170254-70183425 (+)
BALB/cJ	MGP_BALBcJ_G0033707	protein coding gene	Chr8:68449072-68461628 (+)
C3H/HeJ	MGP_C3HHeJ_G0033417	protein coding gene	Chr8:70815087-70828880 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034224	protein coding gene	Chr8:73789816-73805920 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031168	protein coding gene	Chr8:63032147-63044848 (+)
CAST/EiJ	MGP_CASTEiJ_G0032742	protein coding gene	Chr8:70289022-70301952 (+)
CBA/J	MGP_CBAJ_G0033395	protein coding gene	Chr8:76453963-76466836 (+)
DBA/2J	MGP_DBA2J_G0033549	protein coding gene	Chr8:67932822-67945550 (+)
FVB/NJ	MGP_FVBNJ_G0033490	protein coding gene	Chr8:67070652-67083208 (+)
LP/J	MGP_LPJ_G0033636	protein coding gene	Chr8:71131334-71144939 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033533	protein coding gene	Chr8:79085366-79098341 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034242	protein coding gene	Chr8:70349684-70362598 (+)
PWK/PhJ	MGP_PWKPhJ_G0032450	protein coding gene	Chr8:67229996-67243167 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032286	protein coding gene	Chr8:69317880-69330784 (+)
WSB/EiJ	MGP_WSBEiJ_G0032857	protein coding gene	Chr8:70714555-70729005 (+)

Human Ortholog

IL12RB1, interleukin 12 receptor subunit beta 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL12RB1, interleukin 12 receptor subunit beta 1
Synonyms

CD212, IL12RB, IL-12R-BETA1, IMD30
Links

HGNC:5971

NCBI Gene ID: 3594

neXtProt AC: NX_P42701

UniProt: P42701
Chr Location

19p13.11; chr19:18058995-18098944 (-) GRCh38

MGI Vertebrate Homology

Il12rb1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IL12RB1
Gene Tree

Il12rb1

Diseases

1 with human IL12RB1 associations

				Human Disease	Mouse Models
				immunodeficiency 30 IDs immunodeficiency 30 DOID:0111990 NCI:C176800 OMIM:614891 ORDO:319552 UMLS_CUI:C4013949

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 3 genetic backgrounds
53 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

6
Targeted

8
Genomic Mutations

1 involving Il12rb1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased serum IFN-gamma levels in response to recombinant IL-12 or LPS treatment, and failure of ConA-activated splenocytes to proliferate or secrete IFN-gamma in response to IL-12.

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All GO Annotations

22
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

6
cDNA Data

19
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

54
RefSeq

16
UniProt

4
CCDS

CCDS22382.1

Ensembl

ENSMUSG00000000791 (Evidence)
NCBI Gene

16161

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000791	Ensembl Gene Model \| MGI Sequence Detail	12976	C57BL/6J	± kb
transcript	ENSMUST00000000808	Ensembl \| MGI Sequence Detail	2873	Not Applicable
polypeptide	ENSMUSP00000000808	Ensembl \| MGI Sequence Detail	738	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001367 interleukin-12 receptor subunit beta-1

(term hierarchy)
PDB

8CR5, 8OE0, 8PB1
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR050379 Type I Cytokine Receptor
GlyGen

Q60837 13 sites

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All nucleic 21

Genomic 2

cDNA 19

Microarray probesets 4

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MGD-MRK-26013

Summaries

All 97

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 53
Earliest

J:29438 Chua AO, et al., Cloning and characterization of a mouse IL-12 receptor-beta component. J Immunol. 1995 Nov 1;155(9):4286-94
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Il12rb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77831	Chr8:71261022-71261044 (+)	-60 bp
Tssr77832	Chr8:71261075-71261118 (+)	4 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24