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Il12rb1 Gene Detail
Summary
  • Symbol
    Il12rb1
  • Name
    interleukin 12 receptor, beta 1
  • Synonyms
    CD212, IL-12R[b]
  • Feature Type
    protein coding gene
  • IDs
    MGI:104579
    NCBI Gene: 16161
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71261093-71274068 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.21 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104579
 protein coding gene Chr8:71261005-71276186 (+)
129S1/SvImJ ENSMUSG00200026945
 protein coding gene Chr8:66060780-66073742 (+)
A/J ENSMUSG00195016919
 protein coding gene Chr8:66391908-66404887 (+)
AKR/J ENSMUSG00220020969
 protein coding gene Chr8:66306213-66319558 (+)
BALB/cJ ENSMUSG00180023715
 protein coding gene Chr8:66037187-66050149 (+)
C3H/HeJ ENSMUSG00175022021
 protein coding gene Chr8:66317154-66330116 (+)
C57BL/6NJ ENSMUSG00215033822
 protein coding gene Chr8:65994393-66007370 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031168
 protein coding gene Chr8:63032147-63044848 (+)
CAST/EiJ ENSTCUG00005035477
 protein coding gene Chr8:65795902-65808833 (+)
CBA/J ENSMUSG00210029056
 protein coding gene Chr8:66082702-66095666 (+)
DBA/2J ENSMUSG00185013010
 protein coding gene Chr8:72242316-72255278 (+)
FVB/NJ ENSMUSG00205038013
 protein coding gene Chr8:65586933-65599895 (+)
JF1/MsJ ENSUMUG00000038398
 protein coding gene Chr8:74520171-74533136 (+)
LP/J ENSMUSG00230026427
 protein coding gene Chr8:75853820-75866782 (+)
NOD/ShiLtJ ENSMUSG00190022004
 protein coding gene Chr8:66001505-66014482 (+)
NZO/HlLtJ ENSMUSG00225045542
 protein coding gene Chr8:79262984-79275946 (+)
PWK/PhJ ENSLUMG00010028927
 protein coding gene Chr8:65977581-65990534 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005025177
 protein coding gene Chr8:66873706-66886681 (+)



Homology
more
  • Human Ortholog
    IL12RB1, interleukin 12 receptor subunit beta 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL12RB1, interleukin 12 receptor subunit beta 1
  • Synonyms
    CD212, IL12RB, IL-12R-BETA1, IMD30
  • Links
    NCBI Gene ID: 3594
    UniProt: P42701

  • Chr Location
    19p13.11; chr19:18058995-18098944 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human IL12RB1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased serum IFN-gamma levels in response to recombinant IL-12 or LPS treatment, and failure of ConA-activated splenocytes to proliferate or secrete IFN-gamma in response to IL-12.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    33
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    634
  • Tissues
    6
  • cDNA Data
    19
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000791 Ensembl Gene Model | MGI Sequence Detail 12976 C57BL/6J ±  kb
    transcript ENSMUST00000000808 Ensembl | MGI Sequence Detail 2873 Not Applicable  
    polypeptide ENSMUSP00000000808 Ensembl | MGI Sequence Detail 738 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 19

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-26013
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 54
    • Earliest
      J:29438 Chua AO, et al., Cloning and characterization of a mouse IL-12 receptor-beta component. J Immunol. 1995 Nov 1;155(9):4286-94
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory