Gnb4 MGI Mouse Gene Detail - MGI:104581 - guanine nucleotide binding protein (G protein), beta 4

Symbol

Gnb4
Name

guanine nucleotide binding protein (G protein), beta 4
Synonyms

6720453A21Rik

Feature Type

protein coding gene
IDs

MGI:104581
NCBI Gene: 14696
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:32634481-32670734 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 15.78 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

1270 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104581	protein coding gene	Chr3:32632736-32670813 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027140	protein coding gene	Chr3:30195824-30233532 (-)
A/J	MGP_AJ_G0027100	protein coding gene	Chr3:29767903-29804492 (-)
AKR/J	MGP_AKRJ_G0027069	protein coding gene	Chr3:30225210-30261146 (-)
BALB/cJ	MGP_BALBcJ_G0027112	protein coding gene	Chr3:29415436-29451458 (-)
C3H/HeJ	MGP_C3HHeJ_G0026855	protein coding gene	Chr3:30250283-30290892 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027558	protein coding gene	Chr3:31694770-31733081 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024919	protein coding gene	Chr3:27594910-27632558 (-)
CAST/EiJ	MGP_CASTEiJ_G0026308	protein coding gene	Chr3:30114993-30150732 (-)
CBA/J	MGP_CBAJ_G0026832	protein coding gene	Chr3:32543339-32583339 (-)
DBA/2J	MGP_DBA2J_G0026966	protein coding gene	Chr3:29234769-29270622 (-)
FVB/NJ	MGP_FVBNJ_G0026934	protein coding gene	Chr3:28694172-28730395 (-)
LP/J	MGP_LPJ_G0027078	protein coding gene	Chr3:30957655-30997915 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026954	protein coding gene	Chr3:35050806-35087365 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027617	protein coding gene	Chr3:30019731-30056815 (-)
PWK/PhJ	MGP_PWKPhJ_G0026041	protein coding gene	Chr3:28777571-28814102 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025853	protein coding gene	Chr3:29431475-29467983 (-)
WSB/EiJ	MGP_WSBEiJ_G0026382	protein coding gene	Chr3:30039371-30076370 (-)

Human Ortholog

GNB4, G protein subunit beta 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNB4, G protein subunit beta 4
Synonyms

CMTD1F, HG2B
Links

HGNC:20731

NCBI Gene ID: 59345

neXtProt AC: NX_Q9HAV0

UniProt: Q9HAV0
Chr Location

3q26.33; chr3:179396088-179527798 (-) GRCh38

MGI Vertebrate Homology

Gnb4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GNB4
Protein SuperFamily

GN-bd_beta
Gene Tree

Gnb4

Diseases

1 with human GNB4 associations

				Human Disease	Mouse Models
				Charcot-Marie-Tooth disease dominant intermediate F IDs Charcot-Marie-Tooth disease dominant intermediate F DOID:0110206 ICD10CM:G60.0 OMIM:615185 ORDO:352670

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Gene trapped

3
Radiation induced

1
Targeted

2
Genomic Mutations

1 involving Gnb4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

852
Tissues

86
cDNA Data

21
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gnb4

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All Sequences

79
RefSeq

10
UniProt

6
CCDS

CCDS17297.1

Ensembl

ENSMUSG00000027669 (Evidence)
NCBI Gene

14696

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027669	Ensembl Gene Model \| MGI Sequence Detail	36254	C57BL/6J	± kb
transcript	ENSMUST00000108234	Ensembl \| MGI Sequence Detail	2510	Not Applicable
polypeptide	ENSMUSP00000103869	Ensembl \| MGI Sequence Detail	340	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008100 guanine nucleotide-binding protein subunit beta-4

(term hierarchy)
InterPro Domains

IPR001632 G-protein, beta subunit

IPR020472 G-protein beta WD-40 repeat

IPR016346 Guanine nucleotide-binding protein, beta subunit

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

P29387 1 site, 1 O-linked glycan (1 site)

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All nucleic 24

cDNA 21

Primer pair 3

Microarray probesets 5

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MGD-MRK-26015, MGI:1925135

Summaries

All 60

Developmental Gene Expression 10

Diseases 1

Gene Ontology 8

Phenotypes 20
Earliest

J:10436 Danciger M, et al., The gene for the beta-subunit of retinal transducin (Gnb-1) maps to distal mouse chromosome 4, and related sequences map to mouse chromosomes 5 and 8. Genomics. 1990 Mar;6(3):428-35
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gnb4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32936	Chr3:32671024-32671041 (-)	-299 bp
Tssr32935	Chr3:32670822-32670838 (-)	-96 bp
Tssr32934	Chr3:32670628-32670713 (-)	63 bp
Tssr32933	Chr3:32670612-32670622 (-)	117 bp
Tssr32932	Chr3:32669440-32669446 (-)	1,291 bp
Tssr32931	Chr3:32653523-32653532 (-)	17,206 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24