Cnr1 MGI Mouse Gene Detail - MGI:104615

Symbol

Cnr1
Name

cannabinoid receptor 1
Synonyms

CB1, CB1R

Feature Type

protein coding gene
IDs

MGI:104615
NCBI Gene: 12801
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr4:33924593-33948831 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 16.28 cM
Mapping Data

1 experiment

SNPs within 2kb

481 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104615	protein coding gene	Chr4:33923171-33948831 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028124	protein coding gene	Chr4:31479235-31503473 (+)
A/J	MGP_AJ_G0028082	protein coding gene	Chr4:30360546-30384735 (+)
AKR/J	MGP_AKRJ_G0028045	protein coding gene	Chr4:31161707-31185896 (+)
BALB/cJ	MGP_BALBcJ_G0028093	protein coding gene	Chr4:30618634-30643242 (+)
C3H/HeJ	MGP_C3HHeJ_G0027822	protein coding gene	Chr4:31464396-31488840 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028535	protein coding gene	Chr4:32702638-32726825 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025876	protein coding gene	Chr4:28503512-28527716 (+)
CAST/EiJ	MGP_CASTEiJ_G0027277	protein coding gene	Chr4:31235188-31260871 (+)
CBA/J	MGP_CBAJ_G0027794	protein coding gene	Chr4:33776375-33800583 (+)
DBA/2J	MGP_DBA2J_G0027938	protein coding gene	Chr4:30347888-30372296 (+)
FVB/NJ	MGP_FVBNJ_G0027904	protein coding gene	Chr4:29785658-29809864 (+)
LP/J	MGP_LPJ_G0028046	protein coding gene	Chr4:31575686-31599766 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027937	protein coding gene	Chr4:36367193-36391722 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028594	protein coding gene	Chr4:31170723-31194950 (+)
PWK/PhJ	MGP_PWKPhJ_G0026996	protein coding gene	Chr4:30366034-30390763 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026825	protein coding gene	Chr4:31050264-31074457 (+)
WSB/EiJ	MGP_WSBEiJ_G0027353	protein coding gene	Chr4:31175735-31200998 (+)

Human Ortholog

CNR1, cannabinoid receptor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNR1, cannabinoid receptor 1
Synonyms

CANN6, CB1, CB1A, CB1K5, CB1R, CB-R, CNR
Links

HGNC:2159

NCBI Gene ID: 1268

neXtProt AC: NX_P21554

UniProt: P21554
Chr Location

6q15; chr6:88139864-88167349 (-) GRCh38

MGI Vertebrate Homology

Cnr1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CNR1
Protein SuperFamily

Cnoid_rcpt_1
Gene Tree

Cnr1

Diseases

3 with human CNR1 associations

				Human Disease	Mouse Models
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

85 phenotypes from 12 alleles in 20 genetic backgrounds
8 phenotypes from multigenic genotypes
442 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically and radiation induced

1
Endonuclease-mediated

7
Targeted

24
Genomic Mutations

1 involving Cnr1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit abnormal behaviors, altered long term depression and susceptibility to induced seizure.

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All GO Annotations

89
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

991
Tissues

185
cDNA Data

20
Literature Summary

41

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CNR1

ZFIN cnr1

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All Sequences

72
RefSeq

24
UniProt

2
CCDS

CCDS18025.1

Ensembl

ENSMUSG00000044288 (Evidence)
NCBI Gene

12801

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044288	Ensembl Gene Model \| MGI Sequence Detail	24239	C57BL/6J	± kb
transcript	ENSMUST00000057188	Ensembl \| MGI Sequence Detail	5807	Not Applicable
polypeptide	ENSMUSP00000055797	Ensembl \| MGI Sequence Detail	473	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001125 cannabinoid receptor 1

(term hierarchy)
InterPro Domains

IPR002230 Cannabinoid receptor family

IPR000810 Cannabinoid receptor type 1

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

P47746 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

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All nucleic 32

Genomic 6

cDNA 20

Primer pair 2

Other 4

Microarray probesets 6

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MGD-MRK-26052

Summaries

All 608

Developmental Gene Expression 41

Diseases 1

Gene Ontology 11

Phenotypes 442
Earliest

J:29411 Paria BC, et al., The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9460-4
Latest

J:358230 Guo B, et al., CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice. Neuron. 2024 Feb 7;112(3):441-457.e6

TSS for Cnr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36752	Chr4:33923845-33923856 (+)	-742 bp
Tssr36753	Chr4:33924014-33924040 (+)	-566 bp
Tssr36754	Chr4:33924636-33924651 (+)	51 bp
Tssr36755	Chr4:33924921-33924990 (+)	363 bp
Tssr36756	Chr4:33924991-33925012 (+)	409 bp
Tssr36757	Chr4:33925032-33925047 (+)	447 bp
Tssr36758	Chr4:33925076-33925090 (+)	490 bp
Tssr36759	Chr4:33926375-33926384 (+)	1,787 bp
Tssr36760	Chr4:33929586-33929590 (+)	4,995 bp
Tssr36761	Chr4:33945514-33945519 (+)	20,924 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24