Wars1 MGI Mouse Gene Detail - MGI:104630 - tryptophanyl-tRNA synthetase1

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Wars1 Gene Detail

Symbol

Wars1
Name

tryptophanyl-tRNA synthetase1
Synonyms

Wars

Feature Type

protein coding gene
IDs

MGI:104630
NCBI Gene: 22375
Alliance

gene page
Transcription Start Sites

22 TSS

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Sequence Map

Chr12:108825956-108860095 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 59.66 cM, cytoband F2
Mapping Data

2 experiments

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SNPs within 2kb

908 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_104630	protein coding gene	Chr12:108825956-108860100 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020111	protein coding gene	Chr12:111020753-111055813 (-)
A/J	MGP_AJ_G0020065	protein coding gene	Chr12:106797600-106833660 (-)
AKR/J	MGP_AKRJ_G0020041	protein coding gene	Chr12:109895012-109931005 (-)
BALB/cJ	MGP_BALBcJ_G0020051	protein coding gene	Chr12:107220676-107254636 (-)
C3H/HeJ	MGP_C3HHeJ_G0019853	protein coding gene	Chr12:110343796-110378969 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020496	protein coding gene	Chr12:114435691-114470339 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018108	protein coding gene	Chr12:103315367-103355454 (-)
CAST/EiJ	MGP_CASTEiJ_G0019395	protein coding gene	Chr12:105288087-105323246 (-)
CBA/J	MGP_CBAJ_G0019820	protein coding gene	Chr12:119000617-119034686 (-)
DBA/2J	MGP_DBA2J_G0019937	protein coding gene	Chr12:106335048-106370359 (-)
FVB/NJ	MGP_FVBNJ_G0019922	protein coding gene	Chr12:105121648-105161144 (-)
LP/J	MGP_LPJ_G0020012	protein coding gene	Chr12:110883698-110919092 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019960	protein coding gene	Chr12:122139405-122174448 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020525	protein coding gene	Chr12:109380417-109415346 (-)
PWK/PhJ	MGP_PWKPhJ_G0019154	protein coding gene	Chr12:100957422-100992262 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018958	protein coding gene	Chr12:103586456-103620423 (-)
WSB/EiJ	MGP_WSBEiJ_G0019452	protein coding gene	Chr12:110318651-110353472 (-)

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Human Ortholog

WARS1, tryptophanyl-tRNA synthetase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WARS1, tryptophanyl-tRNA synthetase 1
Synonyms

GAMMA-2, HMN9, HMND9, IFI53, IFP53, NEDMSBA, WARS
Links

HGNC:12729

NCBI Gene ID: 7453

neXtProt AC: NX_P23381

UniProt: P23381
Chr Location

14q32.2; chr14:100333790-100376805 (-) GRCh38

MGI Vertebrate Homology

Wars1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WARS1
Gene Tree

Wars1

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Diseases

1 with human WARS1 associations

				Human Disease	Mouse Models
				autosomal dominant distal hereditary motor neuronopathy 9 IDs autosomal dominant distal hereditary motor neuronopathy 9 DOID:0111212 OMIM:617721

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

1
Gene trapped

7
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

32
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

846
Tissues

135
cDNA Data

211
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wars1

ZFIN wars1

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All Sequences

149
RefSeq

18
UniProt

6
CCDS

CCDS26166.1, CCDS49171.1

Ensembl

ENSMUSG00000021266 (Evidence)
NCBI Gene

22375

Representative Sequences				Length	Strain/Species	Flank
	genomic	22375	NCBI Gene Model \| MGI Sequence Detail	34140	C57BL/6J	± kb
	transcript	NM_001164314	RefSeq \| MGI Sequence Detail	2798	C57BL/6
	polypeptide	P32921	UniProt \| EBI \| MGI Sequence Detail	481	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000017369 tryptophan--tRNA ligase, cytoplasmic

(term hierarchy)
EC

6.1.1.2
InterPro Domains

IPR002305 Aminoacyl-tRNA synthetase, class Ic

IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site

IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

IPR002306 Tryptophan-tRNA ligase

IPR009068 uS15/NS1, RNA-binding domain superfamily

IPR000738 WHEP-TRS domain
GlyGen

P32921 1 site, 1 O-linked glycan (1 site)

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All nucleic 214

cDNA 212

Primer pair 2

Microarray probesets 8

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MGD-MRK-26067, MGI:7280669

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Summaries

All 42

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 11
Earliest

J:20958 Pajot B, et al., An alternative splicing modifies the C-terminal end of tryptophanyl-tRNA synthetase in murine embryonic stem cells. J Mol Biol. 1994 Sep 30;242(4):599-603
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Wars1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117735	Chr12:108860042-108860096 (-)	26 bp
Tssr117728	Chr12:108859124-108859141 (-)	962 bp
Tssr117727	Chr12:108855232-108855235 (-)	4,861 bp
Tssr117726	Chr12:108854702-108854709 (-)	5,389 bp
Tssr117725	Chr12:108854676-108854700 (-)	5,407 bp
Tssr117724	Chr12:108854457-108854470 (-)	5,631 bp
Tssr117723	Chr12:108851809-108851817 (-)	8,282 bp
Tssr117722	Chr12:108851725-108851734 (-)	8,365 bp
Tssr117721	Chr12:108850324-108850337 (-)	9,764 bp
Tssr117720	Chr12:108850262-108850272 (-)	9,828 bp
Tssr117719	Chr12:108848710-108848726 (-)	11,377 bp
Tssr117718	Chr12:108848698-108848705 (-)	11,393 bp
Tssr117717	Chr12:108848667-108848694 (-)	11,414 bp
Tssr117716	Chr12:108841569-108841580 (-)	18,520 bp
Tssr117715	Chr12:108841551-108841556 (-)	18,541 bp
Tssr117714	Chr12:108841513-108841542 (-)	18,567 bp
Tssr117713	Chr12:108841496-108841506 (-)	18,594 bp
Tssr117712	Chr12:108841467-108841476 (-)	18,623 bp
Tssr3942	Chr12:108841460-108841465 (-)	18,632 bp
Tssr117711	Chr12:108841446-108841455 (-)	18,644 bp
Tssr117710	Chr12:108839199-108839210 (-)	20,890 bp
Tssr117709	Chr12:108837536-108837543 (-)	22,555 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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