Il15ra MGI Mouse Gene Detail - MGI:104644 - interleukin 15 receptor, alpha chain

Symbol

Il15ra
Name

interleukin 15 receptor, alpha chain

Feature Type

protein coding gene
IDs

MGI:104644
NCBI Gene: 16169
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr2:11710101-11739128 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 8.97 cM
Mapping Data

4 experiments

SNPs within 2kb

877 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104644	protein coding gene	Chr2:11709992-11739129 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025347	protein coding gene	Chr2:9125852-9157985 (+)
A/J	MGP_AJ_G0025324	protein coding gene	Chr2:8712717-8774766 (+)
AKR/J	MGP_AKRJ_G0025293	protein coding gene	Chr2:9018726-9084811 (+)
BALB/cJ	MGP_BALBcJ_G0025320	protein coding gene	Chr2:8726896-8764548 (+)
C3H/HeJ	MGP_C3HHeJ_G0025080	protein coding gene	Chr2:8932502-8994961 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025762	protein coding gene	Chr2:9376870-9411254 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023177	protein coding gene	Chr2:8171238-8202516 (+)
CAST/EiJ	MGP_CASTEiJ_G0024543	protein coding gene	Chr2:9001759-9034898 (+)
CBA/J	MGP_CBAJ_G0025059	protein coding gene	Chr2:9769595-9802551 (+)
DBA/2J	MGP_DBA2J_G0025191	protein coding gene	Chr2:8627142-8688254 (+)
FVB/NJ	MGP_FVBNJ_G0025153	protein coding gene	Chr2:8579409-8609237 (+)
LP/J	MGP_LPJ_G0025277	protein coding gene	Chr2:9006103-9077315 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025185	protein coding gene	Chr2:9648087-9677983 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025820	protein coding gene	Chr2:8974144-9004705 (+)
PWK/PhJ	MGP_PWKPhJ_G0024294	protein coding gene	Chr2:8635380-8666560 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024094	protein coding gene	Chr2:8969541-9003745 (+)
WSB/EiJ	MGP_WSBEiJ_G0024613	protein coding gene	Chr2:9041275-9071675 (+)

Human Ortholog

IL15RA, interleukin 15 receptor subunit alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL15RA, interleukin 15 receptor subunit alpha
Synonyms

CD215
Links

HGNC:5978

NCBI Gene ID: 3601

neXtProt AC: NX_Q13261

UniProt: Q13261
Chr Location

10p15.1; chr10:5943639-5978741 (-) GRCh38

MGI Vertebrate Homology

Il15ra stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IL15RA
Gene Tree

Il15ra

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Phenotype Summary

21 phenotypes from 4 alleles in 7 genetic backgrounds
7 phenotypes from multigenic genotypes
98 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

4
Targeted

9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutation of this gene results in absence of NK cell production in spleen and bone marrow.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

11
cDNA Data

33
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

131
RefSeq

57
UniProt

6
CCDS

CCDS15686.1, CCDS15687.1, CCDS70977.1, CCDS70978.1, CCDS70979.1, CCDS70980.1

Ensembl

ENSMUSG00000023206 (Evidence)
NCBI Gene

16169

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023206	Ensembl Gene Model \| MGI Sequence Detail	29028	C57BL/6J	± kb
transcript	ENSMUST00000078834	Ensembl \| MGI Sequence Detail	1600	Not Applicable
polypeptide	ENSMUSP00000077878	Ensembl \| MGI Sequence Detail	263	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008981 interleukin-15 receptor subunit alpha

(term hierarchy)
PDB

2PSM
InterPro Domains

IPR042372 Interleukin-15 receptor subunit alpha

IPR000436 Sushi/SCR/CCP domain

IPR035976 Sushi/SCR/CCP superfamily
GlyGen

Q60819 1 site

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All nucleic 35

cDNA 34

Primer pair 1

Microarray probesets 4

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MGD-MRK-26082, MGI:2138805

Summaries

All 156

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 98
Earliest

J:28202 Giri JG, et al., Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. 1995 Aug 1;14(15):3654-63
Latest

J:337015 Langenbach M, et al., MDM2 inhibition enhances immune checkpoint inhibitor efficacy by increasing IL-15 and MHC class II production. Mol Cancer Res. 2023 Apr 18;

TSS for Il15ra:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16154	Chr2:11710131-11710157 (+)	43 bp
Tssr16155	Chr2:11710166-11710186 (+)	75 bp
Tssr16156	Chr2:11710201-11710212 (+)	106 bp
Tssr16157	Chr2:11710248-11710259 (+)	153 bp
Tssr16158	Chr2:11710270-11710275 (+)	172 bp
Tssr16159	Chr2:11710541-11710578 (+)	459 bp
Tssr16160	Chr2:11710634-11710643 (+)	538 bp
Tssr16161	Chr2:11716849-11716854 (+)	6,751 bp
Tssr16162	Chr2:11718041-11718053 (+)	7,946 bp
Tssr16163	Chr2:11728064-11728087 (+)	17,975 bp
Tssr16164	Chr2:11728126-11728130 (+)	18,027 bp
Tssr16165	Chr2:11729178-11729184 (+)	19,080 bp
Tssr16166	Chr2:11729812-11729825 (+)	19,718 bp
Tssr16167	Chr2:11729873-11729887 (+)	19,779 bp
Tssr16168	Chr2:11729906-11729919 (+)	19,812 bp
Tssr16169	Chr2:11729925-11729941 (+)	19,832 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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