Fbrs MGI Mouse Gene Detail - MGI:104648

Symbol

Fbrs
Name

fibrosin
Synonyms

Fbs1

Feature Type

protein coding gene
IDs

MGI:104648
NCBI Gene: 14123
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr7:127078371-127090883 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.55 cM, cytoband F4
Mapping Data

1 experiment

SNPs within 2kb

155 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104648	protein coding gene	Chr7:127075925-127090883 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033040	protein coding gene	Chr7:131829796-131842235 (+)
A/J	MGP_AJ_G0033023	protein coding gene	Chr7:128330212-128342508 (+)
AKR/J	MGP_AKRJ_G0032955	protein coding gene	Chr7:131631724-131644154 (+)
BALB/cJ	MGP_BALBcJ_G0033024	protein coding gene	Chr7:127977425-127989891 (+)
C3H/HeJ	MGP_C3HHeJ_G0032738	protein coding gene	Chr7:131533728-131546177 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033533	protein coding gene	Chr7:136973550-136988245 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030506	protein coding gene	Chr7:129520224-129532965 (+)
CAST/EiJ	MGP_CASTEiJ_G0032067	protein coding gene	Chr7:123329673-123345507 (+)
CBA/J	MGP_CBAJ_G0032711	protein coding gene	Chr7:141601203-141616132 (+)
DBA/2J	MGP_DBA2J_G0032863	protein coding gene	Chr7:126304012-126316699 (+)
FVB/NJ	MGP_FVBNJ_G0032816	protein coding gene	Chr7:126150255-126162698 (+)
LP/J	MGP_LPJ_G0032957	protein coding gene	Chr7:133312303-133327536 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032848	protein coding gene	Chr7:142715524-142728491 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033553	protein coding gene	Chr7:130618608-130631690 (+)
PWK/PhJ	MGP_PWKPhJ_G0031774	protein coding gene	Chr7:119312650-119324792 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031620	protein coding gene	Chr7:117430418-117450270 (+)
WSB/EiJ	MGP_WSBEiJ_G0032179	protein coding gene	Chr7:131595933-131608231 (+)

Human Ortholog

FBRS, fibrosin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBRS, fibrosin
Synonyms

FBS, FBS1
Links

HGNC:20442

NCBI Gene ID: 64319

neXtProt AC: NX_Q9HAH7

UniProt: Q9HAH7
Chr Location

16p11.2; chr16:30658431-30670810 (+) GRCh38

MGI Vertebrate Homology

Fbrs stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBRS
Gene Tree

Fbrs

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

46
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbrs

ZFIN fbrs

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All Sequences

52
RefSeq

4
UniProt

5
CCDS

CCDS52408.2

Ensembl

ENSMUSG00000042423 (Evidence)
NCBI Gene

14123

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042423	Ensembl Gene Model \| MGI Sequence Detail	12513	C57BL/6J	± kb
transcript	ENSMUST00000205432	Ensembl \| MGI Sequence Detail	4166	Not Applicable
polypeptide	ENSMUSP00000145783	Ensembl \| MGI Sequence Detail	980	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000029493 probable fibrosin-1

(term hierarchy)
InterPro Domains

IPR023246 Autism susceptibility gene 2 protein

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All nucleic 46

cDNA 46

Microarray probesets 4

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MGD-MRK-26086

Summaries

All 25

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 5
Earliest

J:23960 Prakash S, et al., Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin. Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2154-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fbrs:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2406	Chr7:127077330-127077367 (+)	-1,022 bp
Tssr69221	Chr7:127077379-127077428 (+)	-967 bp
Tssr69222	Chr7:127077666-127077721 (+)	-677 bp
Tssr69223	Chr7:127077725-127077735 (+)	-641 bp
Tssr69224	Chr7:127077968-127078011 (+)	-381 bp
Tssr69225	Chr7:127078015-127078046 (+)	-340 bp
Tssr69226	Chr7:127078115-127078139 (+)	-244 bp
Tssr69227	Chr7:127078155-127078171 (+)	-208 bp
Tssr69228	Chr7:127078186-127078208 (+)	-174 bp
Tssr69229	Chr7:127078220-127078263 (+)	-129 bp
Tssr69230	Chr7:127078266-127078282 (+)	-97 bp
Tssr69231	Chr7:127078363-127078444 (+)	33 bp
Tssr69232	Chr7:127079024-127079037 (+)	660 bp
Tssr69233	Chr7:127079240-127079253 (+)	876 bp
Tssr69234	Chr7:127079788-127079798 (+)	1,422 bp
Tssr69235	Chr7:127080509-127080530 (+)	2,149 bp
Tssr69236	Chr7:127082189-127082279 (+)	3,863 bp
Tssr69237	Chr7:127082280-127082310 (+)	3,924 bp
Tssr69238	Chr7:127084281-127084333 (+)	5,936 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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