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Capzb Gene Detail
Summary
  • Symbol
    Capzb
  • Name
    capping actin protein of muscle Z-line subunit beta
  • Synonyms
    1700120C01Rik, Cappb1, CPB1, CPB2, CPbeta1, CPbeta2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104652
    NCBI Gene: 12345
  • Alliance
    gene page
  • Transcription Start Sites
    36 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:138920210-139019129 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.59 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2290 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104652
 protein coding gene Chr4:138920210-139019131 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029013
 protein coding gene Chr4:142014652-142116980 (+)
A/J MGP_AJ_G0028972
 protein coding gene Chr4:135907641-136006326 (+)
AKR/J MGP_AKRJ_G0028924
 protein coding gene Chr4:139801706-139903961 (+)
BALB/cJ MGP_BALBcJ_G0028996
 protein coding gene Chr4:136585476-136683956 (+)
C3H/HeJ MGP_C3HHeJ_G0028710
 protein coding gene Chr4:140184714-140283359 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029437
 protein coding gene Chr4:147038254-147146444 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026708
 protein coding gene Chr4:128878940-128980534 (+)
CAST/EiJ MGP_CASTEiJ_G0028142
 protein coding gene Chr4:138359492-138458095 (+)
CBA/J MGP_CBAJ_G0028674
 protein coding gene Chr4:151292245-151395984 (+)
DBA/2J MGP_DBA2J_G0028824
 protein coding gene Chr4:136306838-136405384 (+)
FVB/NJ MGP_FVBNJ_G0028791
 protein coding gene Chr4:135325718-135425520 (+)
LP/J MGP_LPJ_G0028923
 protein coding gene Chr4:142089081-142194269 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028817
 protein coding gene Chr4:155182226-155287025 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029475
 protein coding gene Chr4:140330547-140430074 (+)
PWK/PhJ MGP_PWKPhJ_G0027863
 protein coding gene Chr4:133154465-133254277 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027688
 protein coding gene Chr4:136095355-136201196 (+)
WSB/EiJ MGP_WSBEiJ_G0028220
 protein coding gene Chr4:140583827-140684047 (+)



Homology
more
  • Human Ortholog
    CAPZB, capping actin protein of muscle Z-line subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAPZB, capping actin protein of muscle Z-line subunit beta
  • Synonyms
    CAPB, CAPPB, CAPZ
  • Links
    NCBI Gene ID: 832
    neXtProt AC: NX_P47756
    UniProt: P47756

  • Chr Location
    1p36.13; chr1:19338775-19485539 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in the ear exhibit increased ABR threshold, absent DPOE, reduced vestibular function, head shaking and abnormal stereocilia length and width in the cochlea and utricle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    12
  • cDNA Data
    321
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028745 Ensembl Gene Model | MGI Sequence Detail 98920 C57BL/6J ±  kb
    transcript ENSMUST00000030518 Ensembl | MGI Sequence Detail 1390 Not Applicable  
    polypeptide ENSMUSP00000030518 Ensembl | MGI Sequence Detail 301 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000005032 F-actin-capping protein subunit beta
      (term hierarchy)
    • PDB
      7CCC, 7PDZ, 8P94
    • InterPro Domains
      IPR019771 F-actin capping protein, beta subunit, conserved site
      IPR037282 F-actin-capping protein subunit alpha/beta
      IPR042276 F-actin-capping protein subunit alpha/beta, domain 2
      IPR001698 F-actin-capping protein subunit beta
      IPR043175 F-actin-capping protein subunit beta, N-terminal domain
    • GlyGen
      P47757 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 324
      cDNA 322
      Primer pair 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-26092, MGI:1923909, MGI:2140240
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 7
      Gene Ontology 21
      Phenotypes 20
    • Earliest
      J:20868 Schafer DA, et al., Differential localization and sequence analysis of capping protein beta-subunit isoforms of vertebrates. J Cell Biol. 1994 Oct;127(2):453-65
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory