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Lep Gene Detail
Summary
  • Symbol
    Lep
  • Name
    leptin
  • Feature Type
    protein coding gene
  • IDs
    MGI:104663
    NCBI Gene: 16846
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:29060220-29073875 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 12.30 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    428 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104663
 protein coding gene Chr6:29060219-29073876 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030513
 protein coding gene Chr6:26820008-26834944 (+)
A/J MGP_AJ_G0030486
 protein coding gene Chr6:25688256-25701889 (+)
AKR/J MGP_AKRJ_G0030413
 protein coding gene Chr6:26534946-26548578 (+)
BALB/cJ MGP_BALBcJ_G0030496
 protein coding gene Chr6:25849007-25863491 (+)
C3H/HeJ MGP_C3HHeJ_G0030209
 protein coding gene Chr6:26538984-26552610 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030950
 protein coding gene Chr6:27615813-27629766 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028161
 protein coding gene Chr6:23900598-23914290 (+)
CAST/EiJ MGP_CASTEiJ_G0029611
 protein coding gene Chr6:26320802-26335949 (+)
CBA/J MGP_CBAJ_G0030187
 protein coding gene Chr6:28611332-28625002 (+)
DBA/2J MGP_DBA2J_G0030331
 protein coding gene Chr6:25638768-25652405 (+)
FVB/NJ MGP_FVBNJ_G0030285
 protein coding gene Chr6:25390948-25404573 (+)
LP/J MGP_LPJ_G0030418
 protein coding gene Chr6:26960621-26974251 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030321
 protein coding gene Chr6:31158709-31172381 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030980
 protein coding gene Chr6:26403123-26416745 (+)
PWK/PhJ MGP_PWKPhJ_G0029325
 protein coding gene Chr6:25168141-25182246 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029161
 protein coding gene Chr6:26125093-26138694 (+)
WSB/EiJ MGP_WSBEiJ_G0029687
 protein coding gene Chr6:26377038-26390674 (+)



Homology
more
  • Human Ortholog
    LEP, leptin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LEP, leptin
  • Synonyms
    LEPD, OB, OBS
  • Links
    NCBI Gene ID: 3952
    neXtProt AC: NX_P41159
    UniProt: P41159

  • Chr Location
    7q32.1; chr7:128241278-128257629 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with Lep mouse models; 10 with human LEP associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
IDs
 View 3 models
IDs
 View 1 model
IDs
 View 3 models
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    240 phenotypes from 11 alleles in 27 genetic backgrounds
    169 phenotypes from multigenic genotypes
    5 images
    1654 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes are obese, hyperphagic, have low activity, high metabolic efficiency, impaired thermogenesis, infertility and short lifespan in addition to varying other abnormalities. Strain background affects severity and course of diabetes. Heterozygotes survive fasting longer than control mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    186
  • GO References
    38
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    867
  • Tissues
    76
  • cDNA Data
    32
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16846 NCBI Gene Model | MGI Sequence Detail 13656 C57BL/6J ±  kb
    transcript NM_008493 RefSeq | MGI Sequence Detail 3257 ZRU/MplStud  
    polypeptide P41160 UniProt | EBI | MGI Sequence Detail 167 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 12
      cDNA 35
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12967, MGD-MRK-26103
    References
    more
    • Summaries
      All 2067
      Developmental Gene Expression 21
      Diseases 12
      Gene Ontology 38
      Phenotypes 1654
    • Earliest
      J:13066 INGALLS AM, et al., Obese, a new mutation in the house mouse. J Hered. 1950 Dec;41(12):317-8
    • Latest
      J:355016 Wang Y, et al., Therapeutic siRNA targeting PLIN2 ameliorates steatosis, inflammation, and fibrosis in steatotic liver disease models. J Lipid Res. 2024 Aug 24;65(10):100635
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory