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Hmmr Gene Detail
Summary
  • Symbol
    Hmmr
  • Name
    hyaluronan mediated motility receptor (RHAMM)
  • Synonyms
    CD168, Rhamm
  • Feature Type
    protein coding gene
  • IDs
    MGI:104667
    NCBI Gene: 15366
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:40592222-40624249 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 24.40 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1048 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104667
 protein coding gene Chr11:40592215-40624290 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018161
 protein coding gene Chr11:39361938-39399923 (-)
A/J MGP_AJ_G0018134
 protein coding gene Chr11:37873661-37907231 (-)
AKR/J MGP_AKRJ_G0018098
 protein coding gene Chr11:38983428-39020028 (-)
BALB/cJ MGP_BALBcJ_G0018103
 protein coding gene Chr11:38067681-38101670 (-)
C3H/HeJ MGP_C3HHeJ_G0017916
 protein coding gene Chr11:39013224-39047012 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018557
 protein coding gene Chr11:40550577-40584704 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016212
 protein coding gene Chr11:36100274-36135277 (-)
CAST/EiJ MGP_CASTEiJ_G0017480
 protein coding gene Chr11:39036822-39075896 (-)
CBA/J MGP_CBAJ_G0017889
 protein coding gene Chr11:42457137-42494203 (-)
DBA/2J MGP_DBA2J_G0017999
 protein coding gene Chr11:37626034-37658101 (-)
FVB/NJ MGP_FVBNJ_G0017993
 protein coding gene Chr11:37376577-37409716 (-)
LP/J MGP_LPJ_G0018071
 protein coding gene Chr11:39605533-39638700 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018017
 protein coding gene Chr11:43752979-43788194 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018596
 protein coding gene Chr11:39052480-39086168 (-)
PWK/PhJ MGP_PWKPhJ_G0017261
 protein coding gene Chr11:37702099-37733637 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017053
 protein coding gene Chr11:38885072-38918176 (-)
WSB/EiJ MGP_WSBEiJ_G0017529
 protein coding gene Chr11:38774594-38808482 (-)



Homology
more
  • Human Ortholog
    HMMR, hyaluronan mediated motility receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMMR, hyaluronan mediated motility receptor
  • Synonyms
    CD168, IHABP, RHAMM
  • Links
    NCBI Gene ID: 3161
    neXtProt AC: NX_O75330
    UniProt: O75330

  • Chr Location
    5q34; chr5:163460203-163491941 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HMMR associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations of this gene exhibit impaired fertility and are less susceptible to the formation of aggressive fibromatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    4
  • cDNA Data
    123
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020330 Ensembl Gene Model | MGI Sequence Detail 32028 C57BL/6J ±  kb
    transcript ENSMUST00000020579 Ensembl | MGI Sequence Detail 3892 Not Applicable  
    polypeptide ENSMUSP00000020579 Ensembl | MGI Sequence Detail 794 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000001856 hyaluronan mediated motility receptor
      (term hierarchy)
    • InterPro Domains
      IPR031794 Hyaluronan-mediated motility receptor, C-terminal
      IPR026203 Intracellular hyaluronic acid binding protein
    • GlyGen
      Q00547 10 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 133
      Genomic 5
      cDNA 125
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-26076, MGD-MRK-27030, MGI:3034596
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 27
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:349101 Wu H, et al., HMMR triggers immune evasion of hepatocellular carcinoma by inactivation of phagocyte killing. Sci Adv. 2024 Jun 7;10(23):eadl6083
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory