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Man2a1 Gene Detail
Summary
  • Symbol
    Man2a1
  • Name
    mannosidase 2, alpha 1
  • Synonyms
    Mana-2, Mana2, Map-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104669
    NCBI Gene: 17158
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:64907731-65062105 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 33.76 cM, cytoband E1.2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4587 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104669
 protein coding gene Chr17:64907683-65062105 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023974
 protein coding gene Chr17:66689491-66850698 (+)
A/J MGP_AJ_G0023932
 protein coding gene Chr17:64719699-64874727 (+)
AKR/J MGP_AKRJ_G0023901
 protein coding gene Chr17:65602431-65759303 (+)
BALB/cJ MGP_BALBcJ_G0023933
 protein coding gene Chr17:64643819-64799858 (+)
C3H/HeJ MGP_C3HHeJ_G0023697
 protein coding gene Chr17:66479892-66636938 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024379
 protein coding gene Chr17:69309492-69476290 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021825
 protein coding gene Chr17:60809394-60966977 (+)
CAST/EiJ MGP_CASTEiJ_G0023179
 protein coding gene Chr17:66824721-66987000 (+)
CBA/J MGP_CBAJ_G0023673
 protein coding gene Chr17:72061510-72229779 (+)
DBA/2J MGP_DBA2J_G0023801
 protein coding gene Chr17:63471180-63627852 (+)
FVB/NJ MGP_FVBNJ_G0023767
 protein coding gene Chr17:62951176-63105445 (+)
LP/J MGP_LPJ_G0023883
 protein coding gene Chr17:67435549-67595985 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023795
 protein coding gene Chr17:72133547-72295580 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024423
 protein coding gene Chr17:66060091-66221697 (+)
PWK/PhJ MGP_PWKPhJ_G0022925
 protein coding gene Chr17:62734960-62890026 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022736
 protein coding gene Chr17:62746146-62938237 (+)
WSB/EiJ MGP_WSBEiJ_G0023245
 protein coding gene Chr17:66756349-66926111 (+)



Homology
more
  • Human Ortholog
    MAN2A1, mannosidase alpha class 2A member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAN2A1, mannosidase alpha class 2A member 1
  • Synonyms
    AMan II, GOLIM7, MANA2, MANII
  • Links
    NCBI Gene ID: 4124
    neXtProt AC: NX_Q16706
    UniProt: Q16706

  • Chr Location
    5q21.3; chr5:109689927-109869625 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Man2a1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in premature death, dyserythropoiesis, systemic autoimmune disease, including an increase in serum immunoglobulins, glomerulonephritis, and hematuria,
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    96
  • cDNA Data
    95
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024085 Ensembl Gene Model | MGI Sequence Detail 154375 C57BL/6J ±  kb
    transcript ENSMUST00000086723 Ensembl | MGI Sequence Detail 6991 Not Applicable  
    polypeptide ENSMUSP00000083928 Ensembl | MGI Sequence Detail 1150 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000010105 alpha-mannosidase 2
      (term hierarchy)
    • EC
      3.2.1.114
    • InterPro Domains
      IPR011013 Galactose mutarotase-like domain superfamily
      IPR027291 Glycoside hydrolase 38, N-terminal domain superfamily
      IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
      IPR028995 Glycoside hydrolase families 57/38, central domain superfamily
      IPR015341 Glycoside hydrolase family 38, central domain
      IPR037094 Glycoside hydrolase family 38, central domain superfamily
      IPR000602 Glycoside hydrolase family 38, N-terminal domain
      IPR013780 Glycosyl hydrolase, all-beta
      IPR050843 Glycosyl Hydrolase Family 38
      IPR011682 Glycosyl hydrolase family 38, C-terminal
    • GlyGen
      P27046 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 95
      cDNA 95

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12109, MGD-MRK-12110, MGD-MRK-27032
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 16
      Phenotypes 17
    • Earliest
      J:5798 Dizik M, et al., A gene apparently determining the extent of sialylation of lysosomal alpha-mannosidase in mouse liver. Biochem Genet. 1977 Feb;15(1-2):31-46
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory