Fnta MGI Mouse Gene Detail - MGI:104683 - farnesyltransferase, CAAX box, alpha

Symbol

Fnta
Name

farnesyltransferase, CAAX box, alpha
Synonyms

FTA

Feature Type

protein coding gene
IDs

MGI:104683
NCBI Gene: 14272
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:26488716-26505638 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 14.27 cM
Mapping Data

3 experiments

SNPs within 2kb

584 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104683	protein coding gene	Chr8:26488716-26505678 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033494	protein coding gene	Chr8:24083470-24107520 (-)
A/J	MGP_AJ_G0033474	protein coding gene	Chr8:23201890-23219135 (-)
AKR/J	MGP_AKRJ_G0033399	protein coding gene	Chr8:23968415-23986817 (-)
BALB/cJ	MGP_BALBcJ_G0033470	protein coding gene	Chr8:23353418-23371339 (-)
C3H/HeJ	MGP_C3HHeJ_G0033184	protein coding gene	Chr8:24183308-24200546 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033986	protein coding gene	Chr8:25064651-25083661 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030936	protein coding gene	Chr8:20478994-20497888 (-)
CAST/EiJ	MGP_CASTEiJ_G0032510	protein coding gene	Chr8:23630156-23648205 (-)
CBA/J	MGP_CBAJ_G0033159	protein coding gene	Chr8:26041505-26058726 (-)
DBA/2J	MGP_DBA2J_G0033314	protein coding gene	Chr8:23171804-23189132 (-)
FVB/NJ	MGP_FVBNJ_G0033258	protein coding gene	Chr8:22981007-22999814 (-)
LP/J	MGP_LPJ_G0033403	protein coding gene	Chr8:24056524-24075418 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033301	protein coding gene	Chr8:25492183-25510426 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034005	protein coding gene	Chr8:23900747-23917950 (-)
PWK/PhJ	MGP_PWKPhJ_G0032221	protein coding gene	Chr8:22812861-22830589 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032055	protein coding gene	Chr8:23291883-23308843 (-)
WSB/EiJ	MGP_WSBEiJ_G0032626	protein coding gene	Chr8:24122277-24142848 (-)

Human Ortholog

FNTA, farnesyltransferase, CAAX box, subunit alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FNTA, farnesyltransferase, CAAX box, subunit alpha
Synonyms

FPTA, PGGT1A, PTAR2
Links

HGNC:3782

NCBI Gene ID: 2339

neXtProt AC: NX_P49354

UniProt: P49354
Chr Location

8p11.21; chr8:43034194-43085788 (+) GRCh38

MGI Vertebrate Homology

Fnta stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FNTA
Gene Tree

Fnta

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Gene trapped

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

53
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

900
Tissues

67
cDNA Data

163
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fnta

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS22205.1

Ensembl

ENSMUSG00000015994 (Evidence)
NCBI Gene

14272

			Length	Strain/Species	Flank
genomic	14272	NCBI Gene Model \| MGI Sequence Detail	16923	C57BL/6J	± kb
transcript	NM_008033	RefSeq \| MGI Sequence Detail	1924	ZRU/MplStud
polypeptide	Q61239	UniProt \| EBI \| MGI Sequence Detail	377	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007591 protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

(term hierarchy)
EC

2.5.1.58, 2.5.1.59
InterPro Domains

IPR002088 Protein prenyltransferase, alpha subunit
GlyGen

Q61239 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 165

cDNA 163

Primer pair 2

Microarray probesets 4

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MGD-MRK-27046

Summaries

All 49

Developmental Gene Expression 2

Gene Ontology 13

Phenotypes 10
Earliest

J:354358 Seabra MC, et al., Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit. Cell. 1991 May 3;65(3):429-34
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fnta:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr80749	Chr8:26505605-26505654 (-)	8 bp
Tssr80748	Chr8:26491998-26492015 (-)	13,631 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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