Cct4 MGI Mouse Gene Detail - MGI:104689 - chaperonin containing TCP1 subunit 4

Symbol

Cct4
Name

chaperonin containing TCP1 subunit 4
Synonyms

2610204B21Rik, A45, Cctd, T complex protein 1, delta, TCP-1 delta

Feature Type

protein coding gene
IDs

MGI:104689
NCBI Gene: 12464
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:22940593-22953336 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 14.25 cM
Mapping Data

5 experiments

SNPs within 2kb

477 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104689	protein coding gene	Chr11:22940519-22953780 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018083	protein coding gene	Chr11:20705225-20718486 (+)
A/J	MGP_AJ_G0018056	protein coding gene	Chr11:19915621-19928882 (+)
AKR/J	MGP_AKRJ_G0018020	protein coding gene	Chr11:20627604-20642461 (+)
BALB/cJ	MGP_BALBcJ_G0018024	protein coding gene	Chr11:20051022-20064290 (+)
C3H/HeJ	MGP_C3HHeJ_G0017838	protein coding gene	Chr11:20504328-20517598 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018476	protein coding gene	Chr11:21560057-21573309 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016134	protein coding gene	Chr11:18815662-18830569 (+)
CAST/EiJ	MGP_CASTEiJ_G0017399	protein coding gene	Chr11:20557835-20572239 (+)
CBA/J	MGP_CBAJ_G0017812	protein coding gene	Chr11:22516078-22529508 (+)
DBA/2J	MGP_DBA2J_G0017922	protein coding gene	Chr11:19846002-19859262 (+)
FVB/NJ	MGP_FVBNJ_G0017914	protein coding gene	Chr11:19622241-19635713 (+)
LP/J	MGP_LPJ_G0017993	protein coding gene	Chr11:20818762-20833410 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017940	protein coding gene	Chr11:22989175-23002447 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018517	protein coding gene	Chr11:20737197-20750454 (+)
PWK/PhJ	MGP_PWKPhJ_G0017180	protein coding gene	Chr11:19880354-19893383 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016977	protein coding gene	Chr11:20477168-20491408 (+)
WSB/EiJ	MGP_WSBEiJ_G0017453	protein coding gene	Chr11:20362153-20375535 (+)

Human Ortholog

CCT4, chaperonin containing TCP1 subunit 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCT4, chaperonin containing TCP1 subunit 4
Synonyms

Cctd, CCT-DELTA, SRB
Links

HGNC:1617

NCBI Gene ID: 10575

neXtProt AC: NX_P50991

UniProt: P50991
Chr Location

2p15; chr2:61868085-61888671 (-) GRCh38

MGI Vertebrate Homology

Cct4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCT4
Gene Tree

Cct4

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Phenotype Summary

11 phenotype references

All Mutations and Alleles

12
Chemically induced (other)

1
Gene trapped

9
Targeted

2
Genomic Mutations

1 involving Cct4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

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All GO Annotations

34
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

31
cDNA Data

26
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CCT4

Xenbase cct4

ZFIN cct4

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All Sequences

83
RefSeq

2
UniProt

8
CCDS

CCDS24474.1

Ensembl

ENSMUSG00000007739 (Evidence)
NCBI Gene

12464

			Length	Strain/Species	Flank
genomic	12464	NCBI Gene Model \| MGI Sequence Detail	12744	C57BL/6J	± kb
transcript	NM_009837	RefSeq \| MGI Sequence Detail	1966	129/Sv
polypeptide	P80315	UniProt \| EBI \| MGI Sequence Detail	539	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000005152 T-complex protein 1 subunit delta

(term hierarchy)
InterPro Domains

IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)

IPR002423 Chaperonin Cpn60/GroEL/TCP-1 family

IPR002194 Chaperonin TCP-1, conserved site

IPR027409 GroEL-like apical domain superfamily

IPR027413 GroEL-like equatorial domain superfamily

IPR012717 T-complex protein 1, delta subunit

IPR053374 TCP-1 chaperonin-containing T-complex

IPR027410 TCP-1-like chaperonin intermediate domain superfamily
GlyGen

P80315 1 site, 1 O-linked glycan (1 site)

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All nucleic 29

Genomic 1

cDNA 27

Primer pair 1

Microarray probesets 5

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MGD-MRK-27052, MGI:1914415, MGI:2144639

Summaries

All 50

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

TSS for Cct4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3444	Chr11:22940378-22940390 (+)	-209 bp
Tssr100594	Chr11:22940391-22940405 (+)	-195 bp
Tssr100595	Chr11:22940580-22940584 (+)	-11 bp
Tssr100596	Chr11:22940617-22940654 (+)	43 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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