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Scnn1g Gene Detail
Summary
  • Symbol
    Scnn1g
  • Name
    sodium channel, nonvoltage-gated 1 gamma
  • Synonyms
    ENaC gamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:104695
    NCBI Gene: 20278
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:121333702-121367698 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 65.07 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    960 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104695
 protein coding gene Chr7:121333643-121367705 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032944
 protein coding gene Chr7:125774302-125808328 (+)
A/J MGP_AJ_G0032927
 protein coding gene Chr7:122521646-122555824 (+)
AKR/J MGP_AKRJ_G0032859
 protein coding gene Chr7:125636300-125670500 (+)
BALB/cJ MGP_BALBcJ_G0032932
 protein coding gene Chr7:122218344-122253347 (+)
C3H/HeJ MGP_C3HHeJ_G0032642
 protein coding gene Chr7:125557629-125591596 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033438
 protein coding gene Chr7:130742916-130778032 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030410
 protein coding gene Chr7:123858151-123891688 (+)
CAST/EiJ MGP_CASTEiJ_G0031970
 protein coding gene Chr7:117328938-117366135 (+)
CBA/J MGP_CBAJ_G0032615
 protein coding gene Chr7:135111989-135148441 (+)
DBA/2J MGP_DBA2J_G0032767
 protein coding gene Chr7:120535009-120569063 (+)
FVB/NJ MGP_FVBNJ_G0032720
 protein coding gene Chr7:120387217-120421323 (+)
LP/J MGP_LPJ_G0032861
 protein coding gene Chr7:127230419-127264394 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032752
 protein coding gene Chr7:136537150-136574597 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033458
 protein coding gene Chr7:124644769-124678754 (+)
PWK/PhJ MGP_PWKPhJ_G0031678
 protein coding gene Chr7:113456797-113493406 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031524
 protein coding gene Chr7:111411450-111445718 (+)
WSB/EiJ MGP_WSBEiJ_G0032083
 protein coding gene Chr7:125559403-125595116 (+)



Homology
more
  • Human Ortholog
    SCNN1G, sodium channel epithelial 1 subunit gamma
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCNN1G, sodium channel epithelial 1 subunit gamma
  • Synonyms
    BESC3, ENaCg, ENaCgamma, LDLS2, PHA1, PHA1B3, SCNEG
  • Links
    NCBI Gene ID: 6340
    neXtProt AC: NX_P51170
    UniProt: P51170

  • Chr Location
    16p12.2; chr16:23182745-23216883 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Scnn1g mouse models; 3 with human SCNN1G associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in partial lethality between 24-36 hours after birth. Newborns exhibit hyperkalemia, clear lung liquid more slowly, and show low urinary potassium and high urinary sodium concentrations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    846
  • Tissues
    74
  • cDNA Data
    17
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000216 Ensembl Gene Model | MGI Sequence Detail 33997 C57BL/6J ±  kb
    transcript ENSMUST00000000221 Ensembl | MGI Sequence Detail 2991 Not Applicable  
    polypeptide ENSMUSP00000000221 Ensembl | MGI Sequence Detail 655 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 18
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-27058
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 18
      Phenotypes 12
    • Earliest
      J:297461 Canessa CM, et al., Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature. 1994 Feb 3;367(6462):463-7
    • Latest
      J:329933 Akkuratova N, et al., Developmental heterogeneity of embryonic neuroendocrine chromaffin cells and their maturation dynamics. Front Endocrinol (Lausanne). 2022;13:1020000
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory