Nnat MGI Mouse Gene Detail - MGI:104716

Symbol

Nnat
Name

neuronatin
Synonyms

5730414I02Rik, Peg5

Feature Type

protein coding gene
IDs

MGI:104716
NCBI Gene: 18111
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr2:157401998-157404442 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 78.40 cM, cytoband H1
Mapping Data

15 experiments

SNPs within 2kb

81 from dbSNP Build 142
Strain Annotations

18
PCR

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104716	protein coding gene	Chr2:157401936-157404445 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026784	protein coding gene	Chr2:162576006-162578354 (+)
A/J	MGP_AJ_G0026750	protein coding gene	Chr2:156075190-156077631 (+)
AKR/J	MGP_AKRJ_G0026721	protein coding gene	Chr2:160674063-160676507 (+)
BALB/cJ	MGP_BALBcJ_G0026759	protein coding gene	Chr2:156360592-156362940 (+)
C3H/HeJ	MGP_C3HHeJ_G0026501	protein coding gene	Chr2:160978182-160980621 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027208	protein coding gene	Chr2:167410634-167413078 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024578	protein coding gene	Chr2:149526921-149529316 (+)
CAST/EiJ	MGP_CASTEiJ_G0025963	protein coding gene	Chr2:161330831-161333271 (+)
CBA/J	MGP_CBAJ_G0026478	protein coding gene	Chr2:173427527-173429851 (+)
DBA/2J	MGP_DBA2J_G0026616	protein coding gene	Chr2:155249121-155251471 (+)
FVB/NJ	MGP_FVBNJ_G0026583	protein coding gene	Chr2:153643497-153645939 (+)
LP/J	MGP_LPJ_G0026719	protein coding gene	Chr2:162664537-162666893 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026604	protein coding gene	Chr2:177269746-177273123 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027264	protein coding gene	Chr2:160490461-160492901 (+)
PWK/PhJ	MGP_PWKPhJ_G0025697	protein coding gene	Chr2:154772192-154774766 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025500	protein coding gene	Chr2:159430868-159433308 (+)
WSB/EiJ	MGP_WSBEiJ_G0026033	protein coding gene	Chr2:161380560-161385720 (+)

Human Ortholog

NNAT, neuronatin

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NNAT, neuronatin
Synonyms

Peg5
Links

HGNC:7860

NCBI Gene ID: 4826

neXtProt AC: NX_Q16517

UniProt: Q16517
Chr Location

20q11.23; chr20:37521206-37523690 (+) GRCh38

MGI Vertebrate Homology

Nnat stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: NNAT
Gene Tree

Nnat

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Phenotype Summary

15 phenotypes from 4 alleles in 4 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice for a targeted mutation do not exhibit a detected mutant phenotype. Heterozygous mice with a paternally inherited null allele show impaired glucose-stimulated insulin secretion with islets showing a defect in insulin storage.

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1344
Tissues

236
cDNA Data

26
Literature Summary

40

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

81
RefSeq

12
UniProt

10
CCDS

CCDS38306.1, CCDS38307.1, CCDS71174.1, CCDS71175.1, CCDS79857.1

Ensembl

ENSMUSG00000067786 (Evidence)
NCBI Gene

18111

			Length	Strain/Species	Flank
genomic	ENSMUSG00000067786	Ensembl Gene Model \| MGI Sequence Detail	2445	C57BL/6J	± kb
transcript	ENSMUST00000088484	Ensembl \| MGI Sequence Detail	458	Not Applicable
polypeptide	ENSMUSP00000085836	Ensembl \| MGI Sequence Detail	129	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000011296 neuronatin

(term hierarchy)
InterPro Domains

IPR024885 Neuronatin

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All nucleic 42

Genomic 1

cDNA 30

Primer pair 10

Other 1

Microarray probesets 3

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MGD-MRK-27079, MGI:2139297, MGI:2442311

Summaries

All 84

Developmental Gene Expression 40

Gene Ontology 3

Phenotypes 15
Earliest

J:29420 Wijnholds J, et al., Segment-specific expression of the neuronatin gene during early hindbrain development. Dev Biol. 1995 Sep;171(1):73-84
Latest

J:350675 Yu V, et al., Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity. Diabetologia. 2024 Jun;67(6):1079-1094

TSS for Nnat:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21268	Chr2:157402022-157402039 (+)	33 bp
Tssr21269	Chr2:157402493-157402524 (+)	511 bp
Tssr21270	Chr2:157402584-157402595 (+)	592 bp
Tssr21271	Chr2:157402685-157402709 (+)	699 bp
Tssr21272	Chr2:157402732-157402748 (+)	742 bp
Tssr21273	Chr2:157403395-157403405 (+)	1,402 bp
Tssr21274	Chr2:157403637-157403651 (+)	1,646 bp
Tssr21275	Chr2:157403692-157403703 (+)	1,700 bp
Tssr21276	Chr2:157403793-157403816 (+)	1,807 bp
Tssr21277	Chr2:157403822-157403834 (+)	1,830 bp
Tssr21278	Chr2:157403857-157403867 (+)	1,864 bp
Tssr21279	Chr2:157403949-157403952 (+)	1,953 bp
Tssr21280	Chr2:157404028-157404064 (+)	2,048 bp
Tssr21281	Chr2:157404075-157404138 (+)	2,109 bp
Tssr21282	Chr2:157404200-157404211 (+)	2,208 bp
Tssr21283	Chr2:157404214-157404240 (+)	2,229 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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