About   Help   FAQ
Fgf9 Gene Detail
Summary
  • Symbol
    Fgf9
  • Name
    fibroblast growth factor 9
  • Synonyms
    Eks, glia activating factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:104723
    NCBI Gene: 14180
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:58308543-58350311 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 30.51 cM, cytoband D
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    781 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104723
 protein coding gene Chr14:58308004-58350311 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021416
 protein coding gene Chr14:52309931-52353842 (+)
A/J MGP_AJ_G0021377
 protein coding gene Chr14:51243709-51285462 (+)
AKR/J MGP_AKRJ_G0021352
 protein coding gene Chr14:53031597-53080063 (+)
BALB/cJ MGP_BALBcJ_G0021380
 protein coding gene Chr14:51185965-51228014 (+)
C3H/HeJ MGP_C3HHeJ_G0021159
 protein coding gene Chr14:52699192-52745255 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021819
 protein coding gene Chr14:54868107-54910493 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019358
 protein coding gene Chr14:49321688-49363737 (+)
CAST/EiJ MGP_CASTEiJ_G0020677
 protein coding gene Chr14:49047418-49090972 (+)
CBA/J MGP_CBAJ_G0021126
 protein coding gene Chr14:56488255-56533214 (+)
DBA/2J MGP_DBA2J_G0021247
 protein coding gene Chr14:50911851-50954532 (+)
FVB/NJ MGP_FVBNJ_G0021228
 protein coding gene Chr14:50310082-50352372 (+)
LP/J MGP_LPJ_G0021322
 protein coding gene Chr14:53334142-53381174 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021256
 protein coding gene Chr14:55847197-55895356 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021843
 protein coding gene Chr14:52183657-52226690 (+)
PWK/PhJ MGP_PWKPhJ_G0020420
 protein coding gene Chr14:47464094-47506766 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020253
 protein coding gene Chr14:48273968-48318965 (+)
WSB/EiJ MGP_WSBEiJ_G0020729
 protein coding gene Chr14:52501338-52546929 (+)



Homology
more
  • Human Ortholog
    FGF9, fibroblast growth factor 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF9, fibroblast growth factor 9
  • Synonyms
    FGF-9, GAF, HBFG-9, HBGF-9, SYNS3
  • Links
    NCBI Gene ID: 2254
    neXtProt AC: NX_P31371
    UniProt: P31371

  • Chr Location
    13q12.11; chr13:21671073-21704498 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Fgf9 mouse models; 2 with human FGF9 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    151 phenotypes from 10 alleles in 12 genetic backgrounds
    6 phenotypes from multigenic genotypes
    3 images
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced size, pulmonary hypoplasia, cardiac dilation, impaired testes development resulting in male-to-female sex reversal, abnormal retina, and neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    93
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1491
  • Tissues
    468
  • cDNA Data
    35
  • Literature Summary
    196
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14180 NCBI Gene Model | MGI Sequence Detail 41769 C57BL/6J ±  kb
    transcript NM_013518 RefSeq | MGI Sequence Detail 4738 ZRU/MplStud  
    polypeptide P54130 UniProt | EBI | MGI Sequence Detail 208 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      Genomic 6
      cDNA 39
      Primer pair 28
      Other 9

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-27086, MGI:2182125
    References
    more
    • Summaries
      All 303
      Developmental Gene Expression 196
      Diseases 3
      Gene Ontology 24
      Phenotypes 79
    • Earliest
      J:35382 Miyamoto M, et al., Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. Mol Cell Biol. 1993 Jul;13(7):4251-9
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory