Kcnj3 MGI Mouse Gene Detail - MGI:104742 - potassium inwardly-rectifying channel, subfamily J, member 3

Symbol

Kcnj3
Name

potassium inwardly-rectifying channel, subfamily J, member 3
Synonyms

GIRK1, Kcnf3, Kir3.1

Feature Type

protein coding gene
IDs

MGI:104742
NCBI Gene: 16519
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr2:55325982-55488157 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 31.66 cM
Mapping Data

2 experiments

SNPs within 2kb

4795 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104742	protein coding gene	Chr2:55301814-55488157 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025742	protein coding gene	Chr2:54880746-55049294 (+)
A/J	MGP_AJ_G0025718	protein coding gene	Chr2:52784745-52953590 (+)
AKR/J	MGP_AKRJ_G0025688	protein coding gene	Chr2:54300528-54474987 (+)
BALB/cJ	MGP_BALBcJ_G0025713	protein coding gene	Chr2:52875115-53044596 (+)
C3H/HeJ	MGP_C3HHeJ_G0025474	protein coding gene	Chr2:54314533-54486192 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026159	protein coding gene	Chr2:56544445-56723498 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023565	protein coding gene	Chr2:50520088-50683017 (+)
CAST/EiJ	MGP_CASTEiJ_G0024939	protein coding gene	Chr2:54335370-54503359 (+)
CBA/J	MGP_CBAJ_G0025454	protein coding gene	Chr2:58658504-58856654 (+)
DBA/2J	MGP_DBA2J_G0025585	protein coding gene	Chr2:52371193-52539693 (+)
FVB/NJ	MGP_FVBNJ_G0025547	protein coding gene	Chr2:52006916-52163775 (+)
LP/J	MGP_LPJ_G0025673	protein coding gene	Chr2:54763395-54936454 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025578	protein coding gene	Chr2:59902334-60124241 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026217	protein coding gene	Chr2:54206527-54371743 (+)
PWK/PhJ	MGP_PWKPhJ_G0024680	protein coding gene	Chr2:52191566-52355035 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024486	protein coding gene	Chr2:54333485-54497802 (+)
WSB/EiJ	MGP_WSBEiJ_G0025006	protein coding gene	Chr2:54473533-54647269 (+)

Human Ortholog

KCNJ3, potassium inwardly rectifying channel subfamily J member 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNJ3, potassium inwardly rectifying channel subfamily J member 3
Synonyms

GIRK1, KGA, KIR3.1
Links

HGNC:6264

NCBI Gene ID: 3760

neXtProt AC: NX_P48549

UniProt: P48549
Chr Location

2q24.1; chr2:154697855-154858354 (+) GRCh38

MGI Vertebrate Homology

Kcnj3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KCNJ3
Gene Tree

Kcnj3

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Phenotype Summary

13 phenotypes from 2 alleles in 3 genetic backgrounds
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Targeted

5
Genomic Mutations

1 involving Kcnj3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation display slightly increased resting heart rates, and blunted responses to both indirect vagal activation and direct adenosine A1 receptor activation (intended to activate the muscarinic-gated atrial potassium channel).

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All GO Annotations

23
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

56
cDNA Data

9
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnj3

ZFIN kcnj3a, kcnj3b

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All Sequences

79
RefSeq

38
UniProt

3
CCDS

CCDS16042.1, CCDS84524.1

Ensembl

ENSMUSG00000026824 (Evidence)
NCBI Gene

16519

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026824	Ensembl Gene Model \| MGI Sequence Detail	162176	C57BL/6J	± kb
transcript	ENSMUST00000067101	Ensembl \| MGI Sequence Detail	5215	Not Applicable
polypeptide	ENSMUSP00000063329	Ensembl \| MGI Sequence Detail	501	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000002002 G protein-activated inward rectifier potassium channel 1

(term hierarchy)
PDB

1N9P, 1U4E, 2QKS, 3K6N, 5UM4
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR041647 Inward rectifier potassium channel, C-terminal

IPR016449 Potassium channel, inwardly rectifying, Kir

IPR003274 Potassium channel, inwardly rectifying, Kir3.1

IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic

IPR040445 Potassium channel, inwardly rectifying, transmembrane domain
GlyGen

P63250 3 sites, 1 O-linked glycan (2 sites)

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All nucleic 13

Genomic 1

cDNA 9

Primer pair 3

Microarray probesets 6

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MGD-MRK-16305, MGD-MRK-28033

Summaries

All 85

Developmental Gene Expression 10

Gene Ontology 10

Phenotypes 35
Earliest

J:18699 Morishige K, et al., Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel. FEBS Lett. 1994 Jun 13;346(2-3):251-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kcnj3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17777	Chr2:55325800-55325813 (+)	-175 bp
Tssr17778	Chr2:55325815-55325828 (+)	-160 bp
Tssr17779	Chr2:55325902-55325928 (+)	-67 bp
Tssr17780	Chr2:55325930-55325961 (+)	-36 bp
Tssr17781	Chr2:55326400-55326411 (+)	424 bp
Tssr17782	Chr2:55327112-55327194 (+)	1,171 bp
Tssr17783	Chr2:55327202-55327213 (+)	1,226 bp
Tssr17784	Chr2:55327536-55327547 (+)	1,560 bp
Tssr17785	Chr2:55341711-55341715 (+)	15,731 bp
Tssr17786	Chr2:55401554-55401558 (+)	75,574 bp
Tssr17787	Chr2:55487304-55487319 (+)	161,330 bp
Tssr17788	Chr2:55487329-55487355 (+)	161,360 bp
Tssr17789	Chr2:55487360-55487374 (+)	161,385 bp
Tssr17790	Chr2:55487532-55487555 (+)	161,562 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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